2c5r

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[[Image:2c5r.png|left|200px]]
 
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{{STRUCTURE_2c5r| PDB=2c5r | SCENE= }}
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==The structure of phage phi29 replication organizer protein p16.7 in complex with double stranded DNA==
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<StructureSection load='2c5r' size='340' side='right'caption='[[2c5r]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2c5r]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_virus_phi29 Bacillus virus phi29]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C5R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2C5R FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2c5r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c5r OCA], [https://pdbe.org/2c5r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2c5r RCSB], [https://www.ebi.ac.uk/pdbsum/2c5r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2c5r ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/GP167_BPPH2 GP167_BPPH2] Binds to the long stretches of ssDNA of the viral DNA replication intermediates created during the protein-primed mechanism of replication of the viral genome and attaches the viral DNA to the membrane of the infected cells (PubMed:11741949) (PubMed:11169113). Required for the redistribution of replicating viral DNA from the initial replication site to membrane-associated sites surrounding the nucleoid (PubMed:10921898). Required for the second pull step of DNA ejection (PubMed:17526715).<ref>PMID:10921898</ref> <ref>PMID:11169113</ref> <ref>PMID:11741949</ref> <ref>PMID:17526715</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Prokaryotic DNA replication is compartmentalized at the cellular membrane. Functional and biochemical studies showed that the Bacillus subtilis phage 29-encoded membrane protein p16.7 is directly involved in the organization of membrane-associated viral DNA replication. The structure of the functional domain of p16.7 in complex with DNA, presented here, reveals the multimerization mode of the protein and provides insights in the organization of the phage genome at the membrane of the infected cell.
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===THE STRUCTURE OF PHAGE PHI29 REPLICATION ORGANIZER PROTEIN P16.7 IN COMPLEX WITH DOUBLE STRANDED DNA===
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Structural basis for membrane anchorage of viral phi29 DNA during replication.,Albert A, Munoz-Espin D, Jimenez M, Asensio JL, Hermoso JA, Salas M, Meijer WJ J Biol Chem. 2005 Dec 30;280(52):42486-8. Epub 2005 Nov 7. PMID:16275651<ref>PMID:16275651</ref>
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{{ABSTRACT_PUBMED_16275651}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 2c5r" style="background-color:#fffaf0;"></div>
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[[2c5r]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_phage_phi29 Bacillus phage phi29]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C5R OCA].
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== References ==
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<references/>
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==Reference==
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__TOC__
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<ref group="xtra">PMID:016275651</ref><references group="xtra"/>
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</StructureSection>
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[[Category: Bacillus phage phi29]]
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[[Category: Bacillus virus phi29]]
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[[Category: Albert, A.]]
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[[Category: Large Structures]]
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[[Category: Asensio, J L.]]
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[[Category: Albert A]]
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[[Category: Hermoso, J A.]]
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[[Category: Asensio JL]]
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[[Category: Jimenez, M.]]
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[[Category: Hermoso JA]]
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[[Category: Meijer, W J.J.]]
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[[Category: Jimenez M]]
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[[Category: Munoz-Espin, D.]]
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[[Category: Meijer WJJ]]
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[[Category: Salas, M.]]
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[[Category: Munoz-Espin D]]
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[[Category: Dna-binding protein]]
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[[Category: Salas M]]
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[[Category: Dna-binding protein-dna complex]]
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Current revision

The structure of phage phi29 replication organizer protein p16.7 in complex with double stranded DNA

PDB ID 2c5r

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