1q01

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m (Protected "1q01" [edit=sysop:move=sysop])
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[[Image:1q01.png|left|200px]]
 
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{{STRUCTURE_1q01| PDB=1q01 | SCENE= }}
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==Lebetin peptides, a new class of potent aggregation inhibitors==
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<StructureSection load='1q01' size='340' side='right'caption='[[1q01]]' scene=''>
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===Lebetin peptides, a new class of potent aggregation inhibitors===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1q01]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Macrovipera_lebetinus Macrovipera lebetinus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q01 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Q01 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 24 models</td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1q01 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q01 OCA], [https://pdbe.org/1q01 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1q01 RCSB], [https://www.ebi.ac.uk/pdbsum/1q01 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1q01 ProSAT]</span></td></tr>
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[[1q01]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Macrovipera_lebetina Macrovipera lebetina]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q01 OCA].
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</table>
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[[Category: Macrovipera lebetina]]
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== Function ==
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[[Category: Ayeb, M El.]]
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[https://www.uniprot.org/uniprot/LEB_MACLB LEB_MACLB] Lebetins inhibit platelet aggregation induced by thrombin, collagen and PAF-acether. Human platelet aggregation induced by thrombin is inhibited by synthetic lebetin-1-alpha, lebetin-1-beta, lebetin-1-gamma, lebetin-2-alpha and lebetin-2-beta with IC(50) values of 140, 32, 5, 2.5 and 2.8 nM, respectively. Lebetins also inhibit fibrinogen-induced aggregation of alpha-chymotrypsin-treated platelets as well as in vivo collagen-induced thrombocytopenia in rats. Lebetins are not toxic upon intravenous injection into mice and rats.<ref>PMID:11910186</ref> <ref>PMID:8769304</ref> <ref>PMID:9839678</ref>
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[[Category: Darbon, H.]]
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== References ==
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[[Category: Ganzalez, M J.]]
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<references/>
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[[Category: Giralt, E.]]
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__TOC__
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[[Category: Mabrouk, K.]]
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</StructureSection>
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[[Category: Marrakchi, N.]]
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[[Category: Large Structures]]
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[[Category: Mosbah, A.]]
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[[Category: Macrovipera lebetinus]]
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[[Category: Rietschoten, J Van.]]
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[[Category: Darbon H]]
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[[Category: Rochat, H.]]
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[[Category: El Ayeb M]]
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[[Category: Sabatier, J M.]]
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[[Category: Ganzalez MJ]]
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[[Category: Beta-bulged hairpain]]
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[[Category: Giralt E]]
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[[Category: Blood clotting]]
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[[Category: Mabrouk K]]
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[[Category: Marrakchi N]]
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[[Category: Mosbah A]]
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[[Category: Rochat H]]
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[[Category: Sabatier JM]]
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[[Category: Van Rietschoten J]]

Current revision

Lebetin peptides, a new class of potent aggregation inhibitors

PDB ID 1q01

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