1ij2

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (11:23, 2 August 2023) (edit) (undo)
 
(8 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1ij2.png|left|200px]]
 
-
{{STRUCTURE_1ij2| PDB=1ij2 | SCENE= }}
+
==GCN4-pVTL Coiled-coil Trimer with Threonine at the a(16) position==
 +
<StructureSection load='1ij2' size='340' side='right'caption='[[1ij2]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[1ij2]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IJ2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1IJ2 FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
 +
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ij2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ij2 OCA], [https://pdbe.org/1ij2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ij2 RCSB], [https://www.ebi.ac.uk/pdbsum/1ij2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ij2 ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/GCN4_YEAST GCN4_YEAST] Is a transcription factor that is responsible for the activation of more than 30 genes required for amino acid or for purine biosynthesis in response to amino acid or purine starvation. Binds and recognize the DNA sequence: 5'-TGA[CG]TCA-3'.
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
Coiled coils, estimated to constitute 3-5% of the encoded residues in most genomes, are characterized by a heptad repeat, (abcdefg)(n), where the buried a and d positions form the interface between multiple alpha-helices. Although generally hydrophobic, a substantial fraction ( approximately 20%) of these a- and d-position residues are polar or charged. We constructed variants of the well-characterized coiled coil GCN4-p1 with a single polar residue (Asn, Gln, Ser, or Thr) at either an a or a d position. The stability and oligomeric specificity of each variant were measured, and crystal structures of coiled-coil trimers with threonine or serine at either an a or a d position were determined. The structures show how single polar residues in the interface affect not only local packing, but also overall coiled-coil geometry as seen by changes in the Crick supercoil parameters and core cavity volumes.
-
===GCN4-pVTL Coiled-coil Trimer with Threonine at the a(16) position===
+
Buried polar residues in coiled-coil interfaces.,Akey DL, Malashkevich VN, Kim PS Biochemistry. 2001 May 29;40(21):6352-60. PMID:11371197<ref>PMID:11371197</ref>
-
{{ABSTRACT_PUBMED_11371197}}
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 +
</div>
 +
<div class="pdbe-citations 1ij2" style="background-color:#fffaf0;"></div>
-
==About this Structure==
+
==See Also==
-
[[1ij2]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IJ2 OCA].
+
*[[Gcn4 3D Structures|Gcn4 3D Structures]]
-
 
+
*[[Gnc4 3D Structures|Gnc4 3D Structures]]
-
==Reference==
+
== References ==
-
<ref group="xtra">PMID:011371197</ref><references group="xtra"/>
+
<references/>
-
[[Category: Akey, D L.]]
+
__TOC__
-
[[Category: Kim, P S.]]
+
</StructureSection>
-
[[Category: Malashkevich, V N.]]
+
[[Category: Large Structures]]
-
[[Category: Gcn4 coiled coil]]
+
[[Category: Saccharomyces cerevisiae S288C]]
-
[[Category: Transcription]]
+
[[Category: Akey DL]]
 +
[[Category: Kim PS]]
 +
[[Category: Malashkevich VN]]

Current revision

GCN4-pVTL Coiled-coil Trimer with Threonine at the a(16) position

PDB ID 1ij2

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1ij2"
Personal tools