1m4f

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[[Image:1m4f.png|left|200px]]
 
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{{STRUCTURE_1m4f| PDB=1m4f | SCENE= }}
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==Solution Structure of Hepcidin-25==
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<StructureSection load='1m4f' size='340' side='right'caption='[[1m4f]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1m4f]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M4F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1M4F FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1m4f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m4f OCA], [https://pdbe.org/1m4f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1m4f RCSB], [https://www.ebi.ac.uk/pdbsum/1m4f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1m4f ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/HEPC_HUMAN HEPC_HUMAN] Defects in HAMP are the cause of hemochromatosis type 2B (HFE2B) [MIM:[https://omim.org/entry/613313 613313]; also known as juvenile hemochromatosis (JH). HFE2B is a disorder of iron metabolism with excess deposition of iron in the tissues, bronze skin pigmentation, hepatic cirrhosis, arthropathy and diabetes. The most common symptoms of hemochromatosis type 2 at presentation are hypogonadism and cardiomyopathy.<ref>PMID:14633868</ref> <ref>PMID:12915468</ref> <ref>PMID:14630809</ref> <ref>PMID:14670915</ref> <ref>PMID:15099344</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/HEPC_HUMAN HEPC_HUMAN] Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages (By similarity).<ref>PMID:11034317</ref> Has strong antimicrobial activity against E.coli ML35P N.cinerea and weaker against S.epidermidis, S.aureus and group b streptococcus bacteria. Active against the fungus C.albicans. No activity against P.aeruginosa.<ref>PMID:11034317</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The antibacterial and antifungal peptide hepcidin (LEAP-1) is expressed in the liver. This circulating peptide has recently been found to also act as a signaling molecule in iron metabolism. As such, it plays an important role in hereditary hemochromatosis, a serious iron overload disease. In this study, we report the solution structures of the hepcidin-20 and -25 amino acid peptides determined by standard two-dimensional (1)H NMR spectroscopy. These small cysteine-rich peptides form a distorted beta-sheet with an unusual vicinal disulfide bridge found at the turn of the hairpin, which is probably of functional significance. Both peptides exhibit an overall amphipathic structure with six of the eight Cys involved in maintaining interstrand connectivity. Hepcidin-25 assumes major and minor conformations centered about the Pro residue near the N-terminal end. Further NMR diffusion studies indicate that hepcidin-20 exists as a monomer in solution, whereas hepcidin-25 readily aggregates, a property that may contribute to the different activities of the two peptides. The nuclear Overhauser enhancement spectroscopy spectra of the hepcidin-25 aggregates indicate an interface for peptide interactions that again involves the first five residues from the N-terminal end.
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===Solution Structure of Hepcidin-25===
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The solution structure of human hepcidin, a peptide hormone with antimicrobial activity that is involved in iron uptake and hereditary hemochromatosis.,Hunter HN, Fulton DB, Ganz T, Vogel HJ J Biol Chem. 2002 Oct 4;277(40):37597-603. Epub 2002 Jul 22. PMID:12138110<ref>PMID:12138110</ref>
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{{ABSTRACT_PUBMED_12138110}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 1m4f" style="background-color:#fffaf0;"></div>
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[[1m4f]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M4F OCA].
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== References ==
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<references/>
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==Reference==
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__TOC__
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<ref group="xtra">PMID:012138110</ref><references group="xtra"/>
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</StructureSection>
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[[Category: Fulton, D B.]]
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[[Category: Homo sapiens]]
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[[Category: Ganz, T.]]
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[[Category: Large Structures]]
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[[Category: Hunter, H N.]]
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[[Category: Fulton DB]]
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[[Category: Vogel, H J.]]
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[[Category: Ganz T]]
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[[Category: Antimicrobial protein]]
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[[Category: Hunter HN]]
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[[Category: Beta-sheet]]
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[[Category: Vogel HJ]]
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[[Category: Hairpin loop]]
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[[Category: Strand-loop-strand]]
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Current revision

Solution Structure of Hepcidin-25

PDB ID 1m4f

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