2a26

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[[Image:2a26.png|left|200px]]
 
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{{STRUCTURE_2a26| PDB=2a26 | SCENE= }}
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==Crystal structure of the N-terminal, dimerization domain of Siah Interacting Protein==
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<StructureSection load='2a26' size='340' side='right'caption='[[2a26]], [[Resolution|resolution]] 1.20&Aring;' scene=''>
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===Crystal structure of the N-terminal, dimerization domain of Siah Interacting Protein===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2a26]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A26 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2A26 FirstGlance]. <br>
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{{ABSTRACT_PUBMED_16085652}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CXS:3-CYCLOHEXYL-1-PROPYLSULFONIC+ACID'>CXS</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2a26 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a26 OCA], [https://pdbe.org/2a26 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2a26 RCSB], [https://www.ebi.ac.uk/pdbsum/2a26 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2a26 ProSAT]</span></td></tr>
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[[2a26]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A26 OCA].
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</table>
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== Function ==
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==Reference==
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[https://www.uniprot.org/uniprot/CYBP_HUMAN CYBP_HUMAN] May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1).<ref>PMID:16085652</ref>
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<ref group="xtra">PMID:016085652</ref><references group="xtra"/>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Ely, K R.]]
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[[Category: Large Structures]]
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[[Category: Fukushima, T.]]
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[[Category: Ely KR]]
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[[Category: Leone, M.]]
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[[Category: Fukushima T]]
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[[Category: Li, C.]]
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[[Category: Leone M]]
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[[Category: Liddington, R C.]]
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[[Category: Li C]]
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[[Category: Matsuzawa, S.]]
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[[Category: Liddington RC]]
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[[Category: Olson, A J.]]
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[[Category: Matsuzawa S]]
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[[Category: Pellecchia, M.]]
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[[Category: Olson AJ]]
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[[Category: Preece, N E.]]
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[[Category: Pellecchia M]]
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[[Category: Reed, J C.]]
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[[Category: Preece NE]]
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[[Category: Santelli, E.]]
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[[Category: Reed JC]]
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[[Category: Apoptosis]]
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[[Category: Santelli E]]
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[[Category: Dimerization]]
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[[Category: Helical hairpin]]
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Current revision

Crystal structure of the N-terminal, dimerization domain of Siah Interacting Protein

PDB ID 2a26

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