1s4j

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[[Image:1s4j.png|left|200px]]
 
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{{STRUCTURE_1s4j| PDB=1s4j | SCENE= }}
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==NMR structure of cross-reactive peptides from Homo sapiens==
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<StructureSection load='1s4j' size='340' side='right'caption='[[1s4j]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1s4j]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S4J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1S4J FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1s4j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s4j OCA], [https://pdbe.org/1s4j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1s4j RCSB], [https://www.ebi.ac.uk/pdbsum/1s4j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1s4j ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RLA2_HUMAN RLA2_HUMAN] Plays an important role in the elongation step of protein synthesis.[HAMAP-Rule:MF_01478]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The structure of peptides corresponding to the C-terminal residues from Trypanosoma cruzi (R13), human (H13) and Leishmania braziliensis (A13) ribosomal proteins were determined using nuclear magnetic resonance. Although there is only one amino acid difference between them, the peptides present distinct structures in solution: R13 adopts a random coil conformation while H13 and A13 form a bend. Interaction of these peptides with polyclonal antibodies from chronic Chagas' disease patients and a monoclonal antibody raised against T. cruzi ribosomal P2beta protein was probed by transferred NOE. The results show that the flexibility of R13 is fundamental for the binding to the antibody.
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===NMR structure of cross-reactive peptides from Homo sapiens===
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Correlation between conformation and antibody binding: NMR structure of cross-reactive peptides from T. cruzi, human and L. braziliensis.,Soares MR, Bisch PM, Campos de Carvalho AC, Valente AP, Almeida FC FEBS Lett. 2004 Feb 27;560(1-3):134-40. PMID:14988012<ref>PMID:14988012</ref>
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{{ABSTRACT_PUBMED_14988012}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 1s4j" style="background-color:#fffaf0;"></div>
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[[1s4j]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S4J OCA].
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== References ==
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<references/>
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==Reference==
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__TOC__
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<ref group="xtra">PMID:014988012</ref><references group="xtra"/>
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</StructureSection>
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[[Category: Almeida, F C.L.]]
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[[Category: Homo sapiens]]
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[[Category: Bisch, P M.]]
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[[Category: Large Structures]]
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[[Category: Carvalho, A C.Campos de.]]
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[[Category: Almeida FCL]]
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[[Category: Soares, M R.]]
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[[Category: Bisch PM]]
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[[Category: Valente, A P.]]
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[[Category: Campos de Carvalho AC]]
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[[Category: Antigenic peptide]]
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[[Category: Soares MR]]
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[[Category: Chagas disease]]
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[[Category: Valente AP]]
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[[Category: Ribosomal p2 protein]]
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[[Category: Ribosome]]
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Current revision

NMR structure of cross-reactive peptides from Homo sapiens

PDB ID 1s4j

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