2c9n

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[[Image:2c9n.png|left|200px]]
 
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{{STRUCTURE_2c9n| PDB=2c9n | SCENE= }}
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==Structure of the Epstein-Barr virus ZEBRA protein at approximately 3. 5 Angstrom resolution==
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<StructureSection load='2c9n' size='340' side='right'caption='[[2c9n]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2c9n]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_gammaherpesvirus_4 Human gammaherpesvirus 4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C9N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2C9N FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.3&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2c9n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c9n OCA], [https://pdbe.org/2c9n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2c9n RCSB], [https://www.ebi.ac.uk/pdbsum/2c9n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2c9n ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/BZLF1_EBVB9 BZLF1_EBVB9] Plays a key role in the switch from latent infection to lytic cycle producing new virions. Acts as a transcription factor, inducing early lytic cycle genes, and as a origin binding protein for genome replication. BZLF1 activates the promoter of another EBV gene (BSLF2+BMLF1).<ref>PMID:2157874</ref> <ref>PMID:1847997</ref> <ref>PMID:8404860</ref> <ref>PMID:17079287</ref> <ref>PMID:19144704</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Epstein-Barr virus (EBV) causes infectious mononucleosis and is linked to several human malignancies. EBV has a biphasic infection cycle consisting of a latent and a lytic, replicative phase. The switch from latent to lytic infection is triggered by the EBV immediate-early transcription factor ZEBRA (BZLF1, Zta, Z, EB1). We present the crystal structure of ZEBRA's DNA binding domain bound to an EBV lytic gene promoter element. ZEBRA exhibits a variant of the basic-region leucine zipper (bZIP) fold in which a C-terminal moiety stabilizes the coiled coil involved in dimer formation. The structure provides insights into ZEBRA's broad target site specificity, preferential activation of specific EBV promoters in their methylated state, ability to dimerize despite lacking a leucine zipper motif, and failure to heterodimerize with cellular bZIP proteins. The structure will allow for the design of new therapeutic agents that block activation of the EBV lytic cycle.
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===STRUCTURE OF THE EPSTEIN-BARR VIRUS ZEBRA PROTEIN AT APPROXIMATELY 3.5 ANGSTROM RESOLUTION===
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Structural basis of lytic cycle activation by the Epstein-Barr virus ZEBRA protein.,Petosa C, Morand P, Baudin F, Moulin M, Artero JB, Muller CW Mol Cell. 2006 Feb 17;21(4):565-72. PMID:16483937<ref>PMID:16483937</ref>
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{{ABSTRACT_PUBMED_16483937}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 2c9n" style="background-color:#fffaf0;"></div>
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[[2c9n]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_herpesvirus_4 Human herpesvirus 4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C9N OCA].
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== References ==
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<references/>
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==Reference==
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__TOC__
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<ref group="xtra">PMID:016483937</ref><references group="xtra"/>
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</StructureSection>
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[[Category: Human herpesvirus 4]]
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[[Category: Human gammaherpesvirus 4]]
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[[Category: Artero, J B.]]
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[[Category: Large Structures]]
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[[Category: Baudin, F.]]
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[[Category: Artero JB]]
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[[Category: Morand, P.]]
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[[Category: Baudin F]]
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[[Category: Moulin, M.]]
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[[Category: Morand P]]
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[[Category: Muller, C W.]]
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[[Category: Moulin M]]
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[[Category: Petosa, C.]]
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[[Category: Muller CW]]
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[[Category: Bzip protein]]
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[[Category: Petosa C]]
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[[Category: Bzlf1]]
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[[Category: Ebv]]
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[[Category: Epstein-barr virus]]
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[[Category: Lytic cycle activation]]
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[[Category: Nuclear protein]]
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[[Category: Transcription regulation]]
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[[Category: Viral protein]]
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[[Category: Viral protein dna-binding]]
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[[Category: Zebra]]
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[[Category: Zta]]
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Current revision

Structure of the Epstein-Barr virus ZEBRA protein at approximately 3. 5 Angstrom resolution

PDB ID 2c9n

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