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1w7z

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[[Image:1w7z.png|left|200px]]
 
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{{STRUCTURE_1w7z| PDB=1w7z | SCENE= }}
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==Crystal structure of the free (uncomplexed) Ecballium elaterium trypsin inhibitor (EETI-II)==
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<StructureSection load='1w7z' size='340' side='right'caption='[[1w7z]], [[Resolution|resolution]] 1.67&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1w7z]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Ecballium_elaterium Ecballium elaterium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W7Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1W7Z FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.67&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1w7z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w7z OCA], [https://pdbe.org/1w7z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1w7z RCSB], [https://www.ebi.ac.uk/pdbsum/1w7z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1w7z ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ITR2_ECBEL ITR2_ECBEL] Inhibits trypsin.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The Ecballium elaterium trypsin inhibitor II (EETI-II) belongs to the family of squash inhibitors and is one of the strongest inhibitors known for trypsin. The eight independent molecules of EETI-II in the crystal structure reported here provide a good opportunity to test the hypothesis that this small cystine-knot protein (knottin) is sufficiently rigid to be used as a molecular scaffold for protein-engineering purposes. To extend this test, the structures of two complexes of EETI-II with trypsin have also been determined, one carrying a four-amino-acid mutation of EETI-II. The remarkable similarity of these structures confirms the rigidity of the molecular framework and hence its suitability as a molecular scaffold.
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===CRYSTAL STRUCTURE OF THE FREE (UNCOMPLEXED) ECBALLIUM ELATERIUM TRYPSIN INHIBITOR (EETI-II)===
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Structure of Ecballium elaterium trypsin inhibitor II (EETI-II): a rigid molecular scaffold.,Kratzner R, Debreczeni JE, Pape T, Schneider TR, Wentzel A, Kolmar H, Sheldrick GM, Uson I Acta Crystallogr D Biol Crystallogr. 2005 Sep;61(Pt 9):1255-62. Epub 2005, Aug 16. PMID:16131759<ref>PMID:16131759</ref>
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{{ABSTRACT_PUBMED_16131759}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1w7z" style="background-color:#fffaf0;"></div>
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==About this Structure==
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==See Also==
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[[1w7z]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecballium_elaterium Ecballium elaterium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W7Z OCA].
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*[[Trypsin inhibitor 3D structures|Trypsin inhibitor 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:016131759</ref><references group="xtra"/>
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__TOC__
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[[Category: Ecballium elaterium]]
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</StructureSection>
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[[Category: Debreczeni, J E.]]
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[[Category: Kolmar, H.]]
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[[Category: Kraetzner, R.]]
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[[Category: Pape, T.]]
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[[Category: Scheldrick, G M.]]
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[[Category: Schneider, T R.]]
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[[Category: Uson, I.]]
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[[Category: Cystein knot]]
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[[Category: Ecballium elaterium]]
[[Category: Ecballium elaterium]]
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[[Category: Protease inhibitor]]
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[[Category: Large Structures]]
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[[Category: Squash seed inhibitor]]
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[[Category: Debreczeni JE]]
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[[Category: Trypsin]]
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[[Category: Kolmar H]]
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[[Category: Kraetzner R]]
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[[Category: Pape T]]
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[[Category: Scheldrick GM]]
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[[Category: Schneider TR]]
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[[Category: Uson I]]

Current revision

Crystal structure of the free (uncomplexed) Ecballium elaterium trypsin inhibitor (EETI-II)

PDB ID 1w7z

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