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1mmc

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[[Image:1mmc.png|left|200px]]
 
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{{STRUCTURE_1mmc| PDB=1mmc | SCENE= }}
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==1H NMR STUDY OF THE SOLUTION STRUCTURE OF AC-AMP2==
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<StructureSection load='1mmc' size='340' side='right'caption='[[1mmc]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1mmc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Amaranthus_caudatus Amaranthus caudatus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MMC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MMC FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mmc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mmc OCA], [https://pdbe.org/1mmc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mmc RCSB], [https://www.ebi.ac.uk/pdbsum/1mmc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mmc ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/AMP_AMACA AMP_AMACA] Chitin-binding protein with a defensive function against numerous chitin containing fungal pathogens. It is also a potent inhibitor of Gram-positive bacteria.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The conformation in water of antimicrobial protein 2 from Amaranthus caudatus (Ac-AMP2) was determined using 1H NMR, DIANA and restrained molecular modeling. Ac-AMP2 is a 30 amino acid residue, lectin-like protein that specifically binds to chitin, a polymer of beta-1,4-N-acetyl-D-glucosamine. After sequence specific resonance assignments, a total of 198 distance restraints were collected from 2D NOESY buildup spectra at 500 MHz at pH 2, supplemented by a 2D NOESY spectrum at 600 MHz. The location of the three previously unassigned disulfide bridges was determined from preliminary DIANA structures, using a statistical analysis of intercystinyl distances. The solution structure of Ac-AMP2 is presented as a set of 26 DIANA structures, further refined by restrained molecular dynamics using a simulated annealing protocol in the AMBER force field, with a backbone r.m.s.d. for the well defined Glu3-Cys28 segment of 0.69(+/-0.12) angstroms. The main structural element is an antiparallel beta-sheet from Met13 to Lys23 including a betaI-turn over Gln17-Phel8 with a beta bulge at Gly19. In addition, a beta'I turn over Arg6-Gly7, a beta'III turn over Ser11-Gly12 and a helical turn from Gly24 to Cys28 are identified. This structure is very similar to the equivalent regions of the X-ray structure of wheat germ agglutinin and the NMR structure of hevein.
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===1H NMR STUDY OF THE SOLUTION STRUCTURE OF AC-AMP2===
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H NMR study of the solution structure of Ac-AMP2, a sugar binding antimicrobial protein isolated from Amaranthus caudatus.,Martins JC, Maes D, Loris R, Pepermans HA, Wyns L, Willem R, Verheyden P J Mol Biol. 1996 May 3;258(2):322-33. PMID:8627629<ref>PMID:8627629</ref>
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{{ABSTRACT_PUBMED_8627629}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 1mmc" style="background-color:#fffaf0;"></div>
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[[1mmc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Amaranthus_caudatus Amaranthus caudatus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MMC OCA].
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== References ==
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<references/>
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==Reference==
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__TOC__
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<ref group="xtra">PMID:008627629</ref><references group="xtra"/>
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</StructureSection>
[[Category: Amaranthus caudatus]]
[[Category: Amaranthus caudatus]]
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[[Category: Loris, R.]]
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[[Category: Large Structures]]
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[[Category: Maes, D.]]
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[[Category: Loris R]]
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[[Category: Martins, J C.]]
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[[Category: Maes D]]
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[[Category: Pepermans, H A.M.]]
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[[Category: Martins JC]]
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[[Category: Verheyden, P.]]
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[[Category: Pepermans HAM]]
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[[Category: Willem, R.]]
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[[Category: Verheyden P]]
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[[Category: Wyns, L.]]
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[[Category: Willem R]]
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[[Category: Antifungal antimicrobial]]
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[[Category: Wyns L]]
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[[Category: Chitin-binding]]
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Current revision

1H NMR STUDY OF THE SOLUTION STRUCTURE OF AC-AMP2

PDB ID 1mmc

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