8psh

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[[Image:8psh.png|left|200px]]
 
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{{STRUCTURE_8psh| PDB=8psh | SCENE= }}
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==HIGH RESOLUTION NMR STRUCTURE OF THE STEREOREGULAR (ALL-RP)-PHOSPHOROTHIOATE-DNA/RNA HYBRID D (G*PS*C*PS*G*PS*T*PS*C*PS*A*PS*G*PS*G)R(CCUGACGC), MINIMIZED AVERAGE STRUCTURE==
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<StructureSection load='8psh' size='340' side='right'caption='[[8psh]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8psh]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8PSH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8PSH FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AS:2-DEOXY-ADENOSINE+-5-THIO-MONOPHOSPHATE'>AS</scene>, <scene name='pdbligand=GS:GUANOSINE-5-THIO-MONOPHOSPHATE'>GS</scene>, <scene name='pdbligand=PST:THYMIDINE-5-THIOPHOSPHATE'>PST</scene>, <scene name='pdbligand=SC:2-DEOXY-CYTIDINE-5-THIOPHOSPHORATE'>SC</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8psh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8psh OCA], [https://pdbe.org/8psh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8psh RCSB], [https://www.ebi.ac.uk/pdbsum/8psh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8psh ProSAT]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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In this work, we present the first NMR solution structure of a DNA/RNA hybrid containing stereoregular Rp-phosphorothioate modifications of all DNA backbone linkages. The complex of the enzymatically synthesized phosphorothioate DNA octamer (all-Rp)-d(GCGTCAGG) and its complementary RNA r(CCUGACGC) was found to adopt an overall conformation within the A-form family. Most helical parameters and the sugar puckers of the DNA strand assume values intermediate between A- and B-form. The close structural similarity with the unmodified DNA/RNA hybrid of the same sequence may explain why both the natural and the sulfur-substituted complex can be recognized and digested by ribonuclease H.
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===HIGH RESOLUTION NMR STRUCTURE OF THE STEREOREGULAR (ALL-RP)-PHOSPHOROTHIOATE-DNA/RNA HYBRID D (G*PS*C*PS*G*PS*T*PS*C*PS*A*PS*G*PS*G)R(CCUGACGC), MINIMIZED AVERAGE STRUCTURE===
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Structure of a stereoregular phosphorothioate DNA/RNA duplex.,Bachelin M, Hessler G, Kurz G, Hacia JG, Dervan PB, Kessler H Nat Struct Biol. 1998 Apr;5(4):271-6. PMID:9546216<ref>PMID:9546216</ref>
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{{ABSTRACT_PUBMED_9546216}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 8psh" style="background-color:#fffaf0;"></div>
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[[8psh]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8PSH OCA].
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== References ==
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<references/>
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==Reference==
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__TOC__
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<ref group="xtra">PMID:009546216</ref><references group="xtra"/>
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</StructureSection>
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[[Category: Bachelin, M.]]
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[[Category: Large Structures]]
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[[Category: Dervan, P B.]]
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[[Category: Bachelin M]]
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[[Category: Hacia, J G.]]
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[[Category: Dervan PB]]
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[[Category: Hessler, G.]]
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[[Category: Hacia JG]]
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[[Category: Kessler, H.]]
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[[Category: Hessler G]]
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[[Category: Kurz, G.]]
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[[Category: Kessler H]]
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[[Category: Antisense]]
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[[Category: Kurz G]]
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[[Category: Dna-rna hybrid]]
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[[Category: Oligonucleotide]]
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[[Category: Phosphorothioate]]
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[[Category: Thionucleotide]]
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Current revision

HIGH RESOLUTION NMR STRUCTURE OF THE STEREOREGULAR (ALL-RP)-PHOSPHOROTHIOATE-DNA/RNA HYBRID D (G*PS*C*PS*G*PS*T*PS*C*PS*A*PS*G*PS*G)R(CCUGACGC), MINIMIZED AVERAGE STRUCTURE

PDB ID 8psh

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