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4eyf

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[[Image:4eyf.png|left|200px]]
 
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{{STRUCTURE_4eyf| PDB=4eyf | SCENE= }}
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==Crystal structure of NDM-1 bound to hydrolyzed benzylpenicillin==
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<StructureSection load='4eyf' size='340' side='right'caption='[[4eyf]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4eyf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Klebsiella_pneumoniae Klebsiella pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EYF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EYF FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PNK:(2R,4S)-2-{(R)-CARBOXY[(PHENYLACETYL)AMINO]METHYL}-5,5-DIMETHYL-1,3-THIAZOLIDINE-4-CARBOXYLIC+ACID'>PNK</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4eyf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eyf OCA], [https://pdbe.org/4eyf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4eyf RCSB], [https://www.ebi.ac.uk/pdbsum/4eyf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4eyf ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/BLAN1_KLEPN BLAN1_KLEPN] Confers resistance to many beta-lactam antibiotics, including some carbapenems. Does not confer resistance to the polymixin colistin or the fluoroquinolone ciprofloxacin.
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===Crystal structure of NDM-1 bound to hydrolyzed benzylpenicillin===
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==See Also==
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*[[Beta-lactamase 3D structures|Beta-lactamase 3D structures]]
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{{ABSTRACT_PUBMED_22713171}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[4eyf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Klebsiella_pneumoniae Klebsiella pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EYF OCA].
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==Reference==
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<ref group="xtra">PMID:022713171</ref><references group="xtra"/>
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[[Category: Beta-lactamase]]
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[[Category: Klebsiella pneumoniae]]
[[Category: Klebsiella pneumoniae]]
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[[Category: King, D T.]]
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[[Category: Large Structures]]
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[[Category: Strynadka, N C.J.]]
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[[Category: King DT]]
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[[Category: Antibiotic]]
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[[Category: Strynadka NCJ]]
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[[Category: Hydrolase-antibiotic complex]]
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[[Category: Metallo beta lactamase]]
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Current revision

Crystal structure of NDM-1 bound to hydrolyzed benzylpenicillin

PDB ID 4eyf

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