4f45
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of human CD38 E226Q mutant in complex with NAADP== | |
| + | <StructureSection load='4f45' size='340' side='right'caption='[[4f45]], [[Resolution|resolution]] 2.10Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4f45]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F45 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4F45 FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DN4:[[(2R,3R,4R,5R)-5-(6-AMINOPURIN-9-YL)-3-OXIDANYL-4-PHOSPHONOOXY-OXOLAN-2-YL]METHOXY-OXIDANYL-PHOSPHORYL]+[(2R,3S,4R,5R)-5-(3-CARBOXYPYRIDIN-1-IUM-1-YL)-3,4-BIS(OXIDANYL)OXOLAN-2-YL]METHYL+PHOSPHATE'>DN4</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4f45 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4f45 OCA], [https://pdbe.org/4f45 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4f45 RCSB], [https://www.ebi.ac.uk/pdbsum/4f45 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4f45 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/CD38_HUMAN CD38_HUMAN] Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system. | ||
| - | + | ==See Also== | |
| - | + | *[[Cluster of Differentiation CD38|Cluster of Differentiation CD38]] | |
| - | + | __TOC__ | |
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Hao Q]] | ||
| + | [[Category: Lee HC]] | ||
| + | [[Category: Zhang H]] | ||
Current revision
Crystal structure of human CD38 E226Q mutant in complex with NAADP
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Categories: Homo sapiens | Large Structures | Hao Q | Lee HC | Zhang H
