4gaz

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'''Unreleased structure'''
 
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The entry 4gaz is ON HOLD until Paper Publication
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==Crystal Structure of a Jumonji Domain-containing Protein JMJD5==
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<StructureSection load='4gaz' size='340' side='right'caption='[[4gaz]], [[Resolution|resolution]] 2.81&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4gaz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GAZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GAZ FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.81&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=OGA:N-OXALYLGLYCINE'>OGA</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gaz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gaz OCA], [https://pdbe.org/4gaz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gaz RCSB], [https://www.ebi.ac.uk/pdbsum/4gaz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gaz ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/KDM8_HUMAN KDM8_HUMAN] Histone demethylase required for G2/M phase cell cycle progression. Specifically demethylates dimethylated 'Lys-36' (H3K36me2) of histone H3, an epigenetic repressive mark, thereby acting as a transcription activator. Regulates expression of CCNA1 (cyclin-A1), leading to regulate cancer cell proliferation.
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Authors: Wang, H., Zhou, X., Zhang, X., Tao, Y., Chen, N., Zang, J.
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==See Also==
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*[[Jumonji domain-containing protein 3D structures|Jumonji domain-containing protein 3D structures]]
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Description: Crystal Structure of a Jumonji Domain-containing Protein JMJD5
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Chen N]]
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[[Category: Tao Y]]
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[[Category: Wang H]]
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[[Category: Zang J]]
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[[Category: Zhang X]]
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[[Category: Zhou X]]

Current revision

Crystal Structure of a Jumonji Domain-containing Protein JMJD5

PDB ID 4gaz

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