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1ix1

From Proteopedia

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[[Image:1ix1.gif|left|200px]]<br /><applet load="1ix1" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="1ix1, resolution 1.85&Aring;" />
 
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'''Crystal Structure of P.aeruginosa Peptide deformylase Complexed with Antibiotic Actinonin'''<br />
 
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==About this Structure==
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==Crystal Structure of P.aeruginosa Peptide deformylase Complexed with Antibiotic Actinonin==
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1IX1 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa] with <scene name='pdbligand=ZN:'>ZN</scene>, <scene name='pdbligand=BB2:'>BB2</scene> and <scene name='pdbligand=MHA:'>MHA</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Peptide_deformylase Peptide deformylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.88 3.5.1.88] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IX1 OCA].
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<StructureSection load='1ix1' size='340' side='right'caption='[[1ix1]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
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== Structural highlights ==
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==Reference==
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<table><tr><td colspan='2'>[[1ix1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IX1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1IX1 FirstGlance]. <br>
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Crystal structure of peptide deformylase from Staphylococcus aureus in complex with actinonin, a naturally occurring antibacterial agent., Yoon HJ, Kim HL, Lee SK, Kim HW, Kim HW, Lee JY, Mikami B, Suh SW, Proteins. 2004 Nov 15;57(3):639-42. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15382235 15382235]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
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[[Category: Peptide deformylase]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BB2:ACTINONIN'>BB2</scene>, <scene name='pdbligand=MHA:(CARBAMOYLMETHYL-CARBOXYMETHYL-AMINO)-ACETIC+ACID'>MHA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ix1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ix1 OCA], [https://pdbe.org/1ix1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ix1 RCSB], [https://www.ebi.ac.uk/pdbsum/1ix1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ix1 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DEF_PSEAE DEF_PSEAE] Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ix/1ix1_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ix1 ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Pseudomonas aeruginosa]]
[[Category: Pseudomonas aeruginosa]]
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[[Category: Single protein]]
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[[Category: Ahn HJ]]
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[[Category: Ahn, H J.]]
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[[Category: Han BW]]
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[[Category: Han, B W.]]
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[[Category: Kim H-W]]
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[[Category: Kim, H W.]]
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[[Category: Lee BI]]
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[[Category: Lee, B I.]]
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[[Category: Lee HH]]
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[[Category: Lee, H H.]]
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[[Category: Lee JY]]
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[[Category: Lee, J Y.]]
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[[Category: Suh SW]]
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[[Category: Suh, S W.]]
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[[Category: Yang JK]]
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[[Category: Yang, J K.]]
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[[Category: Yoon H-J]]
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[[Category: Yoon, H J.]]
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[[Category: BB2]]
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[[Category: MHA]]
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[[Category: ZN]]
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[[Category: protein-inhibitor complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:16:33 2008''
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Current revision

Crystal Structure of P.aeruginosa Peptide deformylase Complexed with Antibiotic Actinonin

PDB ID 1ix1

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