1ixx

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[[Image:1ixx.gif|left|200px]]<br /><applet load="1ixx" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="1ixx, resolution 2.5&Aring;" />
 
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'''CRYSTAL STRUCTURE OF COAGULATION FACTORS IX/X-BINDING PROTEIN (IX/X-BP) FROM VENOM OF HABU SNAKE WITH A HETERODIMER OF C-TYPE LECTIN DOMAINS'''<br />
 
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==Overview==
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==CRYSTAL STRUCTURE OF COAGULATION FACTORS IX/X-BINDING PROTEIN (IX/X-BP) FROM VENOM OF HABU SNAKE WITH A HETERODIMER OF C-TYPE LECTIN DOMAINS==
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<StructureSection load='1ixx' size='340' side='right'caption='[[1ixx]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1ixx]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Protobothrops_flavoviridis Protobothrops flavoviridis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IXX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1IXX FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ixx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ixx OCA], [https://pdbe.org/1ixx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ixx RCSB], [https://www.ebi.ac.uk/pdbsum/1ixx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ixx ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SL9A_PROFL SL9A_PROFL] Anticoagulant protein which binds to the gamma-carboxyglutamic acid-domain regions of factors IX (F9) and factor X (F10) in the presence of calcium with a 1 to 1 stoichiometry.<ref>PMID:2613688</ref> <ref>PMID:7925387</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ix/1ixx_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ixx ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
Coagulation factors IX/X-binding protein is an intertwined dimer with a central loop projecting into the adjoining subunit. Excluding this loop, each subunit has a fold similar to rat mannose-binding protein.
Coagulation factors IX/X-binding protein is an intertwined dimer with a central loop projecting into the adjoining subunit. Excluding this loop, each subunit has a fold similar to rat mannose-binding protein.
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==About this Structure==
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Structure of coagulation factors IX/X-binding protein, a heterodimer of C-type lectin domains.,Mizuno H, Fujimoto Z, Koizumi M, Kano H, Atoda H, Morita T Nat Struct Biol. 1997 Jun;4(6):438-41. PMID:9187649<ref>PMID:9187649</ref>
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1IXX is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Trimeresurus_flavoviridis Trimeresurus flavoviridis] with <scene name='pdbligand=CA:'>CA</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Known structural/functional Sites: <scene name='pdbsite=S1:Ca-Binding+Site'>S1</scene>, <scene name='pdbsite=S2:Ca-Binding+Site'>S2</scene>, <scene name='pdbsite=S3:Ca-Binding+Site'>S3</scene>, <scene name='pdbsite=S4:Ca-Binding+Site'>S4</scene>, <scene name='pdbsite=S5:Ca-Binding+Site'>S5</scene> and <scene name='pdbsite=S6:Ca-Binding+Site'>S6</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IXX OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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Structure of coagulation factors IX/X-binding protein, a heterodimer of C-type lectin domains., Mizuno H, Fujimoto Z, Koizumi M, Kano H, Atoda H, Morita T, Nat Struct Biol. 1997 Jun;4(6):438-41. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9187649 9187649]
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</div>
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[[Category: Protein complex]]
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<div class="pdbe-citations 1ixx" style="background-color:#fffaf0;"></div>
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[[Category: Trimeresurus flavoviridis]]
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== References ==
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[[Category: Fujimoto, Z.]]
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<references/>
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[[Category: Kano, H.]]
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__TOC__
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[[Category: Koizumi, M.]]
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</StructureSection>
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[[Category: Mizuno, H.]]
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[[Category: Large Structures]]
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[[Category: CA]]
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[[Category: Protobothrops flavoviridis]]
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[[Category: c-type crd motif]]
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[[Category: Fujimoto Z]]
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[[Category: c-type lectin]]
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[[Category: Kano H]]
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[[Category: coagulation factor binding]]
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[[Category: Koizumi M]]
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[[Category: gla-domain binding]]
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[[Category: Mizuno H]]
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[[Category: loop exchanged dimer]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:16:49 2008''
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Current revision

CRYSTAL STRUCTURE OF COAGULATION FACTORS IX/X-BINDING PROTEIN (IX/X-BP) FROM VENOM OF HABU SNAKE WITH A HETERODIMER OF C-TYPE LECTIN DOMAINS

PDB ID 1ixx

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