This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


4g3e

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (11:25, 1 March 2024) (edit) (undo)
 
(6 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:4g3e.jpg|left|200px]]
 
-
{{STRUCTURE_4g3e| PDB=4g3e | SCENE= }}
+
==Crystal structure of murine NF-kappaB inducing kinase (NIK) bound to a 6-alkynylindoline (cmp1)==
-
 
+
<StructureSection load='4g3e' size='340' side='right'caption='[[4g3e]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
-
===Crystal structure of murine NF-kappaB inducing kinase (NIK) bound to a 6-alkynylindoline (cmp1)===
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[4g3e]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G3E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4G3E FirstGlance]. <br>
-
 
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
-
==About this Structure==
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0WC:(2R)-4-[1-(2-AMINO-5-CHLOROPYRIMIDIN-4-YL)-2,3-DIHYDRO-1H-INDOL-6-YL]-2-(1,3-THIAZOL-2-YL)BUT-3-YN-2-OL'>0WC</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-
[[4g3e]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G3E OCA].
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4g3e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g3e OCA], [https://pdbe.org/4g3e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4g3e RCSB], [https://www.ebi.ac.uk/pdbsum/4g3e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4g3e ProSAT]</span></td></tr>
-
[[Category: Mitogen-activated protein kinase kinase kinase]]
+
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/M3K14_MOUSE M3K14_MOUSE] Lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of NF-kappa-B and its transcriptional activity. Promotes proteolytic processing of NFKB2/P100, which leads to activation of NF-kappa-B via the non-canonical pathway. Could act in a receptor-selective manner.<ref>PMID:11239468</ref>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
-
[[Category: G., de Leon-Boenig.]]
+
[[Category: Hymowitz SG]]
-
[[Category: Hymowitz, S G.]]
+
[[Category: De Leon-Boenig G]]
-
[[Category: Map3k14]]
+
-
[[Category: Nf-kappab]]
+
-
[[Category: Non-rd kinase]]
+
-
[[Category: Protein serine/threonine kinase]]
+
-
[[Category: Structure-based drug design]]
+
-
[[Category: Transferase]]
+
-
[[Category: Transferase-transferase inhibitor complex]]
+

Current revision

Crystal structure of murine NF-kappaB inducing kinase (NIK) bound to a 6-alkynylindoline (cmp1)

PDB ID 4g3e

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4g3e"
Personal tools