4g3e

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[[Image:4g3e.jpg|left|200px]]
 
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{{STRUCTURE_4g3e| PDB=4g3e | SCENE= }}
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==Crystal structure of murine NF-kappaB inducing kinase (NIK) bound to a 6-alkynylindoline (cmp1)==
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<StructureSection load='4g3e' size='340' side='right'caption='[[4g3e]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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===Crystal structure of murine NF-kappaB inducing kinase (NIK) bound to a 6-alkynylindoline (cmp1)===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4g3e]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G3E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4G3E FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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==About this Structure==
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0WC:(2R)-4-[1-(2-AMINO-5-CHLOROPYRIMIDIN-4-YL)-2,3-DIHYDRO-1H-INDOL-6-YL]-2-(1,3-THIAZOL-2-YL)BUT-3-YN-2-OL'>0WC</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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[[4g3e]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G3E OCA].
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4g3e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g3e OCA], [https://pdbe.org/4g3e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4g3e RCSB], [https://www.ebi.ac.uk/pdbsum/4g3e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4g3e ProSAT]</span></td></tr>
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[[Category: Mitogen-activated protein kinase kinase kinase]]
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/M3K14_MOUSE M3K14_MOUSE] Lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of NF-kappa-B and its transcriptional activity. Promotes proteolytic processing of NFKB2/P100, which leads to activation of NF-kappa-B via the non-canonical pathway. Could act in a receptor-selective manner.<ref>PMID:11239468</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: G., de Leon-Boenig.]]
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[[Category: Hymowitz SG]]
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[[Category: Hymowitz, S G.]]
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[[Category: De Leon-Boenig G]]
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[[Category: Map3k14]]
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[[Category: Nf-kappab]]
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[[Category: Non-rd kinase]]
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[[Category: Protein serine/threonine kinase]]
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[[Category: Structure-based drug design]]
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[[Category: Transferase]]
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[[Category: Transferase-transferase inhibitor complex]]
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Current revision

Crystal structure of murine NF-kappaB inducing kinase (NIK) bound to a 6-alkynylindoline (cmp1)

PDB ID 4g3e

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