This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1qks

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
(New page: 200px<br /> <applet load="1qks" size="450" color="white" frame="true" align="right" spinBox="true" caption="1qks, resolution 1.28&Aring;" /> '''CYTOCHROME CD1 NITR...)
Current revision (06:04, 17 April 2024) (edit) (undo)
 
(24 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1qks.gif|left|200px]]<br />
 
-
<applet load="1qks" size="450" color="white" frame="true" align="right" spinBox="true"
 
-
caption="1qks, resolution 1.28&Aring;" />
 
-
'''CYTOCHROME CD1 NITRITE REDUCTASE, OXIDISED FORM'''<br />
 
-
==Overview==
+
==CYTOCHROME CD1 NITRITE REDUCTASE, OXIDISED FORM==
-
Cytochrome cd1-nitrite reductase is a bifunctional enzyme that catalyzes, the one-electron reduction of nitrite to nitric oxide and the, four-electron reduction of oxygen to water. The 1.55 A crystal structure, of the dimeric enzyme from Thiosphaera pantotropha is reported here. The, protein was sequenced from the X-ray structure. Each subunit contains a, covalent c heme with two axial His ligands (His-17, His-69) and a unique, noncovalent d1 heme ligated by Tyr-25 and His-200. The d1 heme is the, mononuclear iron center where both oxygen and nitrite reduction take, place. The two types of heme are located in separate domains whose, arrangement suggests a mechanism requiring domain movement during, catalysis.
+
<StructureSection load='1qks' size='340' side='right'caption='[[1qks]], [[Resolution|resolution]] 1.28&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[1qks]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Paracoccus_pantotrophus Paracoccus pantotrophus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QKS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QKS FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.28&#8491;</td></tr>
 +
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DHE:HEME+D'>DHE</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HEC:HEME+C'>HEC</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qks FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qks OCA], [https://pdbe.org/1qks PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qks RCSB], [https://www.ebi.ac.uk/pdbsum/1qks PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qks ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/NIRS_PARPN NIRS_PARPN]
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qk/1qks_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1qks ConSurf].
 +
<div style="clear:both"></div>
-
==About this Structure==
+
==See Also==
-
1QKS is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Paracoccus_denitrificans Paracoccus denitrificans]] with SO4, HEC, DHE and GOL as [[http://en.wikipedia.org/wiki/ligands ligands]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1QKS OCA]].
+
*[[Cytochrome C 3D structures|Cytochrome C 3D structures]]
-
 
+
*[[Cytochrome c nitrite reductase|Cytochrome c nitrite reductase]]
-
==Reference==
+
__TOC__
-
The anatomy of a bifunctional enzyme: structural basis for reduction of oxygen to water and synthesis of nitric oxide by cytochrome cd1., Fulop V, Moir JW, Ferguson SJ, Hajdu J, Cell. 1995 May 5;81(3):369-77. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=7736589 7736589]
+
</StructureSection>
-
[[Category: Paracoccus denitrificans]]
+
[[Category: Large Structures]]
-
[[Category: Single protein]]
+
[[Category: Paracoccus pantotrophus]]
-
[[Category: Fulop, V.]]
+
[[Category: Fulop V]]
-
[[Category: DHE]]
+
-
[[Category: GOL]]
+
-
[[Category: HEC]]
+
-
[[Category: SO4]]
+
-
[[Category: denitrification]]
+
-
[[Category: electron transport]]
+
-
[[Category: enzyme]]
+
-
[[Category: nitrite reductase]]
+
-
[[Category: oxidoreductase]]
+
-
[[Category: periplasmic]]
+
-
 
+
-
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Oct 29 16:11:13 2007''
+

Current revision

CYTOCHROME CD1 NITRITE REDUCTASE, OXIDISED FORM

PDB ID 1qks

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1qks"
Personal tools