1j3c
From Proteopedia
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| - | [[Image:1j3c.gif|left|200px]]<br /><applet load="1j3c" size="350" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="1j3c" /> | ||
| - | '''Solution structure of the C-terminal domain of the HMGB2'''<br /> | ||
| - | == | + | ==Solution structure of the C-terminal domain of the HMGB2== |
| - | + | <StructureSection load='1j3c' size='340' side='right'caption='[[1j3c]]' scene=''> | |
| - | [ | + | == Structural highlights == |
| - | [[ | + | <table><tr><td colspan='2'>[[1j3c]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J3C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1J3C FirstGlance]. <br> |
| - | [[ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1j3c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1j3c OCA], [https://pdbe.org/1j3c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1j3c RCSB], [https://www.ebi.ac.uk/pdbsum/1j3c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1j3c ProSAT]</span></td></tr> | |
| - | [ | + | </table> |
| - | [[ | + | == Function == |
| - | [ | + | [https://www.uniprot.org/uniprot/HMGB2_PIG HMGB2_PIG] DNA binding proteins that associates with chromatin and has the ability to bend DNA. Binds preferentially single-stranded DNA. Involved in V(D)J recombination by acting as a cofactor of the RAG complex. Acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS) (By similarity). |
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/j3/1j3c_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1j3c ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| - | + | ==See Also== | |
| + | *[[High mobility group protein|High mobility group protein]] | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Sus scrofa]] | ||
| + | [[Category: Kurita J]] | ||
| + | [[Category: Shimahara H]] | ||
| + | [[Category: Tate S]] | ||
| + | [[Category: Yoshida M]] | ||
Current revision
Solution structure of the C-terminal domain of the HMGB2
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