1j5y

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[[Image:1j5y.gif|left|200px]]<br /><applet load="1j5y" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="1j5y, resolution 2.30&Aring;" />
 
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'''Crystal structure of transcriptional regulator (TM1602) from Thermotoga maritima at 2.3 A resolution'''<br />
 
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==About this Structure==
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==Crystal structure of transcriptional regulator (TM1602) from Thermotoga maritima at 2.3 A resolution==
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1J5Y is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima] with <scene name='pdbligand=NI:'>NI</scene> and <scene name='pdbligand=K:'>K</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J5Y OCA].
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<StructureSection load='1j5y' size='340' side='right'caption='[[1j5y]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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== Structural highlights ==
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==Reference==
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<table><tr><td colspan='2'>[[1j5y]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J5Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1J5Y FirstGlance]. <br>
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Crystal structure of a transcription regulator (TM1602) from Thermotoga maritima at 2.3 A resolution., Weekes D, Miller MD, Krishna SS, McMullan D, McPhillips TM, Acosta C, Canaves JM, Elsliger MA, Floyd R, Grzechnik SK, Jaroszewski L, Klock HE, Koesema E, Kovarik JS, Kreusch A, Morse AT, Quijano K, Spraggon G, van den Bedem H, Wolf G, Hodgson KO, Wooley J, Deacon AM, Godzik A, Lesley SA, Wilson IA, Proteins. 2007 Apr 1;67(1):247-52. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17256761 17256761]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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[[Category: Single protein]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1j5y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1j5y OCA], [https://pdbe.org/1j5y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1j5y RCSB], [https://www.ebi.ac.uk/pdbsum/1j5y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1j5y ProSAT], [https://www.topsan.org/Proteins/JCSG/1j5y TOPSAN]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NIAR_THEMA NIAR_THEMA] Probably functions to regulate transcription of NAD metabolic genes. Binds to DNA upstream of the probable nadBII/nadA/nadC and niaRP operons in a nicotinic acid dependent fashion. Nicotinic acid may be a corepressor.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/j5/1j5y_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1j5y ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Thermotoga maritima]]
[[Category: Thermotoga maritima]]
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[[Category: JCSG, Joint Center for Structural Genomics.]]
 
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[[Category: K]]
 
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[[Category: NI]]
 
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[[Category: biotin repressor family]]
 
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[[Category: conserved hypothetical protein]]
 
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[[Category: jcsg]]
 
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[[Category: joint center for structural genomics]]
 
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[[Category: protein structure initiative]]
 
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[[Category: psi]]
 
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[[Category: structural genomics]]
 
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[[Category: tm1602]]
 
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[[Category: transcriptional regulator]]
 
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:19:17 2008''
 

Current revision

Crystal structure of transcriptional regulator (TM1602) from Thermotoga maritima at 2.3 A resolution

PDB ID 1j5y

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