This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
4gkt
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 4gkt is ON HOLD Authors: Immekus, F., Klebe, G. Description: tRNA Guanine Transglycosylase in complex with disubstituted lin-benzoguanine inhibitor) |
|||
| (7 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==tRNA Guanine Transglycosylase in complex with disubstituted lin-benzoguanine inhibitor== | |
| + | <StructureSection load='4gkt' size='340' side='right'caption='[[4gkt]], [[Resolution|resolution]] 1.53Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4gkt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Zymomonas_mobilis_subsp._mobilis_ZM4_=_ATCC_31821 Zymomonas mobilis subsp. mobilis ZM4 = ATCC 31821]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GKT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GKT FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.53Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0O1:6-AMINO-4-{2-[(CYCLOPENTYLMETHYL)AMINO]ETHYL}-2-[(2-PHENYLETHYL)AMINO]-3,7-DIHYDRO-8H-IMIDAZO[4,5-G]QUINAZOLIN-8-ONE'>0O1</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gkt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gkt OCA], [https://pdbe.org/4gkt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gkt RCSB], [https://www.ebi.ac.uk/pdbsum/4gkt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gkt ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/TGT_ZYMMO TGT_ZYMMO] Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).[HAMAP-Rule:MF_00168] | ||
| - | + | ==See Also== | |
| - | + | *[[TRNA-guanine transglycosylase 3D structures|TRNA-guanine transglycosylase 3D structures]] | |
| - | + | __TOC__ | |
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Zymomonas mobilis subsp. mobilis ZM4 = ATCC 31821]] | ||
| + | [[Category: Immekus F]] | ||
| + | [[Category: Klebe G]] | ||
Current revision
tRNA Guanine Transglycosylase in complex with disubstituted lin-benzoguanine inhibitor
| |||||||||||
