4dvq
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | The entry | + | ==Structure of human aldosterone synthase, CYP11B2, in complex with deoxycorticosterone== |
| + | <StructureSection load='4dvq' size='340' side='right'caption='[[4dvq]], [[Resolution|resolution]] 2.49Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4dvq]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DVQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DVQ FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.49Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1CA:DESOXYCORTICOSTERONE'>1CA</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4dvq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dvq OCA], [https://pdbe.org/4dvq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4dvq RCSB], [https://www.ebi.ac.uk/pdbsum/4dvq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4dvq ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/C11B2_HUMAN C11B2_HUMAN] Familial hyperreninemic hypoaldosteronism type 1;Familial hyperaldosteronism type I. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The molecular defect causing hyperaldosteronism familial 1 is an anti-Lepore-type fusion of the CYP11B1 and CYP11B2 genes. The hybrid gene has the promoting part of CYP11B1, ACTH-sensitive, and the coding part of CYP11B2. | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/C11B2_HUMAN C11B2_HUMAN] Preferentially catalyzes the conversion of 11-deoxycorticosterone to aldosterone via corticosterone and 18-hydroxycorticosterone.<ref>PMID:23322723</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Cytochrome P450 3D structures|Cytochrome P450 3D structures]] | |
| - | + | == References == | |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Arrowsmith C]] | ||
| + | [[Category: Edwards A]] | ||
| + | [[Category: Park H-W]] | ||
| + | [[Category: Shen L]] | ||
| + | [[Category: Strushkevich N]] | ||
| + | [[Category: Tempel W]] | ||
| + | [[Category: Usanov SA]] | ||
Current revision
Structure of human aldosterone synthase, CYP11B2, in complex with deoxycorticosterone
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Categories: Homo sapiens | Large Structures | Arrowsmith C | Edwards A | Park H-W | Shen L | Strushkevich N | Tempel W | Usanov SA
