4gjt

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'''Unreleased structure'''
 
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The entry 4gjt is ON HOLD until Paper Publication
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==complex structure of nectin-4 bound to MV-H==
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<StructureSection load='4gjt' size='340' side='right'caption='[[4gjt]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4gjt]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Measles_virus_strain_Ichinose-B95a Measles virus strain Ichinose-B95a]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GJT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GJT FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.1001&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gjt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gjt OCA], [https://pdbe.org/4gjt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gjt RCSB], [https://www.ebi.ac.uk/pdbsum/4gjt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gjt ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/HEMA_MEASC HEMA_MEASC] Attaches the virus to cell receptors and thereby initiating infection. Binding of H protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion. May use human CD46 and/or SLAMF1 as receptors for viral entry into the cell. The high degree of interaction between H and MCP/CD46 results in down-regulation of the latter from the surface of infected cells, rendering them more sensitive to c3b-mediated complement lysis (By similarity).
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Measles virus is a major public health concern worldwide. Three measles virus cell receptors have been identified so far, and the structures of the first two in complex with measles virus hemagglutinin (MV-H) have been reported. Nectin-4 is the most recently identified receptor in epithelial cells, and its binding mode to MV-H remains elusive. In this study, we solved the structure of the membrane-distal domain of human nectin-4 in complex with MV-H. The structure shows that nectin-4 binds the MV-H beta4-beta5 groove exclusively via its N-terminal IgV domain; the contact interface is dominated by hydrophobic interactions. The binding site in MV-H for nectin-4 also overlaps extensively with those of the other two receptors. Finally, a hydrophobic pocket centered in the beta4-beta5 groove is involved in binding to all three identified measles virus receptors, representing a potential target for antiviral drugs.
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Authors: Zhang, X., Lu, G., Qi, J., Li, Y., He, Y., Xu, X., Shi, J., Zhang, C., Yan, J., Gao, G.F.
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Structure of measles virus hemagglutinin bound to its epithelial receptor nectin-4.,Zhang X, Lu G, Qi J, Li Y, He Y, Xu X, Shi J, Zhang CW, Yan J, Gao GF Nat Struct Mol Biol. 2013 Jan;20(1):67-72. doi: 10.1038/nsmb.2432. Epub 2012 Dec , 2. PMID:23202587<ref>PMID:23202587</ref>
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Description: complex structure of nectin-4 bound to MV-H
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 4gjt" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Poliovirus receptor-related protein|Poliovirus receptor-related protein]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Measles virus strain Ichinose-B95a]]
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[[Category: Gao GF]]
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[[Category: He Y]]
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[[Category: Li Y]]
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[[Category: Lu G]]
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[[Category: Qi J]]
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[[Category: Shi J]]
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[[Category: Xu X]]
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[[Category: Yan J]]
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[[Category: Zhang C]]
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[[Category: Zhang X]]

Current revision

complex structure of nectin-4 bound to MV-H

PDB ID 4gjt

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