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1jeo

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[[Image:1jeo.gif|left|200px]]<br /><applet load="1jeo" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="1jeo, resolution 2.0&Aring;" />
 
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'''Crystal Structure of the Hypothetical Protein MJ1247 from Methanococcus jannaschii at 2.0 A Resolution Infers a Molecular Function of 3-Hexulose-6-Phosphate isomerase.'''<br />
 
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==Overview==
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==Crystal Structure of the Hypothetical Protein MJ1247 from Methanococcus jannaschii at 2.0 A Resolution Infers a Molecular Function of 3-Hexulose-6-Phosphate isomerase.==
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The crystal structure of the hypothetical protein MJ1247 from Methanococccus jannaschii at 2 A resolution, a detailed sequence analysis, and biochemical assays infer its molecular function to be 3-hexulose-6-phosphate isomerase (PHI). In the dissimilatory ribulose monophosphate (RuMP) cycle, ribulose-5-phosphate is coupled to formaldehyde by the 3-hexulose-6-phosphate synthase (HPS), yielding hexulose-6-phosphate, which is then isomerized to fructose-6-phosphate by the enzyme 3-hexulose-6-phosphate isomerase. MJ1247 is an alpha/beta structure consisting of a five-stranded parallel beta sheet flanked on both sides by alpha helices, forming a three-layered alpha-beta-alpha sandwich. The fold represents the nucleotide binding motif of a flavodoxin type. MJ1247 is a tetramer in the crystal and in solution and each monomer has a folding similar to the isomerase domain of glucosamine-6-phosphate synthase (GlmS).
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<StructureSection load='1jeo' size='340' side='right'caption='[[1jeo]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[1jeo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JEO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JEO FirstGlance]. <br>
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1JEO is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii] with <scene name='pdbligand=CIT:'>CIT</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JEO OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene></td></tr>
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==Reference==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jeo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jeo OCA], [https://pdbe.org/1jeo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jeo RCSB], [https://www.ebi.ac.uk/pdbsum/1jeo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jeo ProSAT], [https://www.topsan.org/Proteins/BSGC/1jeo TOPSAN]</span></td></tr>
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Crystal structure of MJ1247 protein from M. jannaschii at 2.0 A resolution infers a molecular function of 3-hexulose-6-phosphate isomerase., Martinez-Cruz LA, Dreyer MK, Boisvert DC, Yokota H, Martinez-Chantar ML, Kim R, Kim SH, Structure. 2002 Feb;10(2):195-204. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11839305 11839305]
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PHI_METJA PHI_METJA] Catalyzes the isomerization between 3-hexulose 6-phosphate and fructose 6-phosphate.<ref>PMID:11839305</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/je/1jeo_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jeo ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Methanocaldococcus jannaschii]]
[[Category: Methanocaldococcus jannaschii]]
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[[Category: Single protein]]
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[[Category: Boisvert DC]]
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[[Category: BSGC, Berkeley Structural Genomics Center.]]
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[[Category: Dreyer MK]]
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[[Category: Boisvert, D C.]]
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[[Category: Kim R]]
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[[Category: Dreyer, M K.]]
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[[Category: Kim SH]]
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[[Category: Kim, R.]]
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[[Category: Martinez-Chantar ML]]
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[[Category: Kim, S H.]]
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[[Category: Martinez-Cruz LA]]
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[[Category: Martinez-Chantar, M L.]]
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[[Category: Yokota H]]
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[[Category: Martinez-Cruz, L A.]]
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[[Category: Yokota, H.]]
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[[Category: CIT]]
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[[Category: 3-hexulose-6-phosphate isomerase]]
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[[Category: berkeley structural genomics center]]
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[[Category: bsgc structure funded by nih]]
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[[Category: phi]]
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[[Category: phosphosugar]]
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[[Category: protein structure initiative]]
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[[Category: psi]]
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[[Category: rump pathway]]
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[[Category: structural genomics]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:21:48 2008''
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Current revision

Crystal Structure of the Hypothetical Protein MJ1247 from Methanococcus jannaschii at 2.0 A Resolution Infers a Molecular Function of 3-Hexulose-6-Phosphate isomerase.

PDB ID 1jeo

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