3v35

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[[Image:3v35.jpg|left|200px]]
 
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{{STRUCTURE_3v35| PDB=3v35 | SCENE= }}
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==Aldose reductase complexed with a nitro compound==
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<StructureSection load='3v35' size='340' side='right'caption='[[3v35]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3v35]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V35 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3V35 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMF:DIMETHYLFORMAMIDE'>DMF</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=NTI:2-[(5-NITRO-1,3-THIAZOL-2-YL)CARBAMOYL]PHENYL+ACETATE'>NTI</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3v35 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v35 OCA], [https://pdbe.org/3v35 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3v35 RCSB], [https://www.ebi.ac.uk/pdbsum/3v35 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3v35 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ALDR_HUMAN ALDR_HUMAN] Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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A little is more than enough: Aldose reductase (AR) is a potential target in a wide range of diseases but its utility may be limited by the side effects caused by complete inhibition. Furthermore, known inhibitors of AR have suffered in clinical evaluation due to poor bioavailability. Here, the clinically used antiprotozoal drug nitazoxanide with proven bioavailability has been shown to partially inhibit AR, potentially circumventing the negatives effects of complete enzyme inhibition.
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===Aldose reductase complexed with a nitro compound===
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Partial Inhibition of Aldose Reductase by Nitazoxanide and Its Molecular Basis.,Zheng X, Zhang L, Chen W, Chen Y, Xie W, Hu X ChemMedChem. 2012 Aug 13. doi: 10.1002/cmdc.201200333. PMID:22890894<ref>PMID:22890894</ref>
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{{ABSTRACT_PUBMED_22890894}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3v35" style="background-color:#fffaf0;"></div>
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==About this Structure==
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==See Also==
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[[3v35]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V35 OCA].
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*[[Aldose reductase 3D structures|Aldose reductase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:022890894</ref><references group="xtra"/>
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__TOC__
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[[Category: Aldehyde reductase]]
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Chen, Y.]]
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[[Category: Large Structures]]
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[[Category: Hu, X.]]
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[[Category: Chen Y]]
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[[Category: Luo, H.]]
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[[Category: Hu X]]
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[[Category: Zhang, L.]]
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[[Category: Luo H]]
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[[Category: Zheng, X.]]
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[[Category: Zhang L]]
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[[Category: Aldose reductase]]
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[[Category: Zheng X]]
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[[Category: Oxidoreductase]]
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Current revision

Aldose reductase complexed with a nitro compound

PDB ID 3v35

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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