4g0p

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[[Image:4g0p.png|left|200px]]
 
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{{STRUCTURE_4g0p| PDB=4g0p | SCENE= }}
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==Crystal Structure of Arabidopsis thaliana AGO1 MID domain in complex with UMP==
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<StructureSection load='4g0p' size='340' side='right'caption='[[4g0p]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4g0p]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G0P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4G0P FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=U5P:URIDINE-5-MONOPHOSPHATE'>U5P</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4g0p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g0p OCA], [https://pdbe.org/4g0p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4g0p RCSB], [https://www.ebi.ac.uk/pdbsum/4g0p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4g0p ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/AGO1_ARATH AGO1_ARATH] Involved in RNA-mediated post-transcriptional gene silencing (PTGS). Main component of the RNA-induced silencing complex (RISC) that binds to a short guide RNA such as microRNA (miRNA) or small interfering RNA (siRNA). RISC uses the mature miRNA or siRNA as a guide for slicer-directed cleavage of homologous mRNAs to repress gene expression. Requires DRB1 for directional loading of the small RNA duplex (guide stand and passenger strand) onto RISC for passenger strand degradation. Unlike animal RISC that associates in high molecular weight complex, Arabidopsis RISC is probably composed only of the AGO1 protein and associated RNA without any other proteins. Associates mainly with miRNAs of 21 nucleotide in length and preferentially recruits small RNAs with a 5' terminal uridine. Associates with 22 nucleotide miRNAs to trigger RDR6-dependent secondary siRNAs biogenesis. This pathway amplifies silencing by using the target RNA as substrate to generate secondary siRNAs. Binds to miR168 which targets its own mRNA for repression, establishing a homeostatic regulatory loop. Involved in antiviral RNA silencing by contributing to viral RNA clearance. Is capable of targeting viral RNAs with more compact structures than AGO7 which favors less structured RNA targets. May not associate with 24 nucleotide siRNAs involved in chromatin silencing. Essential for multiple processes in development. Essential for proper development of leaves and floral organs, and formation of axillary meristems. Like AGO10, required for stem cell function and organ polarity.<ref>PMID:9427751</ref> <ref>PMID:15882589</ref> <ref>PMID:16081530</ref> <ref>PMID:17158744</ref> <ref>PMID:18342361</ref> <ref>PMID:18342362</ref> <ref>PMID:18344228</ref> <ref>PMID:18799732</ref> <ref>PMID:20562854</ref> <ref>PMID:19763164</ref> <ref>PMID:19861421</ref>
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===Crystal Structure of Arabidopsis thaliana AGO1 MID domain in complex with UMP===
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==See Also==
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*[[Argonaute 3D structures|Argonaute 3D structures]]
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{{ABSTRACT_PUBMED_22850669}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[4g0p]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G0P OCA].
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:022850669</ref><references group="xtra"/>
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[[Category: Arabidopsis thaliana]]
[[Category: Arabidopsis thaliana]]
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[[Category: Frank, F.]]
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[[Category: Large Structures]]
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[[Category: Hauver, J.]]
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[[Category: Frank F]]
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[[Category: Nagar, B.]]
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[[Category: Hauver J]]
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[[Category: Sonenberg, N.]]
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[[Category: Nagar B]]
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[[Category: Gene regulation]]
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[[Category: Sonenberg N]]
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[[Category: Mid domain]]
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[[Category: Small rna 5' nucleotide recognition]]
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Current revision

Crystal Structure of Arabidopsis thaliana AGO1 MID domain in complex with UMP

PDB ID 4g0p

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