1jgg

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[[Image:1jgg.gif|left|200px]]<br /><applet load="1jgg" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="1jgg, resolution 2.&Aring;" />
 
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'''Even-skipped Homeodomain Complexed to AT-rich DNA'''<br />
 
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==Overview==
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==Even-skipped Homeodomain Complexed to AT-rich DNA==
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even-skipped is a homeobox gene important in controlling segment patterning in the embryonic fruit fly. Its homeobox encodes a DNA binding domain which binds with similar affinities to two DNA consensus sequences, one AT-rich, the other GC-rich. We describe a crystallographic analysis of the Even-skipped homeodomain complexed to an AT-rich oligonucleotide at 2.0 A resolution. The structure reveals a novel arrangement of two homeodomains bound to one 10 bp DNA sequence in a tandem fashion. This arrangement suggests a mechanism for the homeoproteins' regulatory specificity. In addition, the functionally important residue Gln50 is observed in multiple conformations making direct and water-mediated hydrogen bonds with the DNA bases.
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<StructureSection load='1jgg' size='340' side='right'caption='[[1jgg]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[1jgg]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JGG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JGG FirstGlance]. <br>
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1JGG is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JGG OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jgg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jgg OCA], [https://pdbe.org/1jgg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jgg RCSB], [https://www.ebi.ac.uk/pdbsum/1jgg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jgg ProSAT]</span></td></tr>
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==Reference==
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</table>
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Structure of the even-skipped homeodomain complexed to AT-rich DNA: new perspectives on homeodomain specificity., Hirsch JA, Aggarwal AK, EMBO J. 1995 Dec 15;14(24):6280-91. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8557047 8557047]
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== Function ==
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[https://www.uniprot.org/uniprot/EVE_DROME EVE_DROME] May play a role in determining neuronal identity. May be directly involved in specifying identity of individual neurons. Pair-rule protein required for segmentation; involved in transforming the broad, spatial, aperiodic expression patterns of the gap genes into a system of precise periodic expression patterns of the pair-rule and segmentary polarity genes.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jg/1jgg_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jgg ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
[[Category: Drosophila melanogaster]]
[[Category: Drosophila melanogaster]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Aggarwal, A K.]]
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[[Category: Aggarwal AK]]
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[[Category: Hirsch, J A.]]
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[[Category: Hirsch JA]]
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[[Category: even-skipped]]
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[[Category: homeodomain]]
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[[Category: protein-dna complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:22:21 2008''
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Current revision

Even-skipped Homeodomain Complexed to AT-rich DNA

PDB ID 1jgg

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