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1jhn

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[[Image:1jhn.gif|left|200px]]<br /><applet load="1jhn" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="1jhn, resolution 2.9&Aring;" />
 
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'''Crystal Structure of the Lumenal Domain of Calnexin'''<br />
 
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==Overview==
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==Crystal Structure of the Lumenal Domain of Calnexin==
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The three-dimensional structure of the lumenal domain of the lectin-like chaperone calnexin determined to 2.9 A resolution reveals an extended 140 A arm inserted into a beta sandwich structure characteristic of legume lectins. The arm is composed of tandem repeats of two proline-rich sequence motifs which interact with one another in a head-to-tail fashion. Identification of the ligand binding site establishes calnexin as a monovalent lectin, providing insight into the mechanism by which the calnexin family of chaperones interacts with monoglucosylated glycoproteins.
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<StructureSection load='1jhn' size='340' side='right'caption='[[1jhn]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[1jhn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Canis_lupus_familiaris Canis lupus familiaris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JHN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JHN FirstGlance]. <br>
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1JHN is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Canis_lupus_familiaris Canis lupus familiaris] with <scene name='pdbligand=CA:'>CA</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JHN OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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==Reference==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jhn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jhn OCA], [https://pdbe.org/1jhn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jhn RCSB], [https://www.ebi.ac.uk/pdbsum/1jhn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jhn ProSAT]</span></td></tr>
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The Structure of calnexin, an ER chaperone involved in quality control of protein folding., Schrag JD, Bergeron JJ, Li Y, Borisova S, Hahn M, Thomas DY, Cygler M, Mol Cell. 2001 Sep;8(3):633-44. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11583625 11583625]
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CALX_CANLF CALX_CANLF] Calcium-binding protein that interacts with newly synthesized monoglucosylated glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at the synapse (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jh/1jhn_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jhn ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
[[Category: Canis lupus familiaris]]
[[Category: Canis lupus familiaris]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Bergeron, J M.]]
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[[Category: Bergeron JM]]
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[[Category: Borisova, S.]]
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[[Category: Borisova S]]
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[[Category: Cygler, M.]]
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[[Category: Cygler M]]
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[[Category: Hahn, M.]]
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[[Category: Hahn M]]
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[[Category: Li, Y.]]
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[[Category: Li Y]]
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[[Category: Schrag, J D.]]
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[[Category: Schrag JD]]
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[[Category: Thomas, D Y.]]
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[[Category: Thomas DY]]
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[[Category: CA]]
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[[Category: beta sandwich]]
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[[Category: jelly-roll]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:22:43 2008''
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Current revision

Crystal Structure of the Lumenal Domain of Calnexin

PDB ID 1jhn

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