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4fxh

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[[Image:4fxh.jpg|left|200px]]
 
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{{STRUCTURE_4fxh| PDB=4fxh | SCENE= }}
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==Crystal structure of the isolated E. coli RelE toxin, P212121 form==
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<StructureSection load='4fxh' size='340' side='right'caption='[[4fxh]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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===Crystal structure of the isolated E. coli RelE toxin, P212121 form===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4fxh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FXH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FXH FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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==About this Structure==
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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[[4fxh]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FXH OCA].
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fxh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fxh OCA], [https://pdbe.org/4fxh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fxh RCSB], [https://www.ebi.ac.uk/pdbsum/4fxh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fxh ProSAT]</span></td></tr>
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[[Category: Escherichia coli]]
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</table>
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[[Category: Boggild, A.]]
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== Function ==
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[[Category: Brodersen, D E.]]
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[https://www.uniprot.org/uniprot/RELE_ECOLI RELE_ECOLI] Toxic component of a toxin-antitoxin (TA) module. A sequence-specific, ribosome-dependent mRNA endoribonuclease that inhibits translation during amino acid starvation (the stringent response). Acts by cleaving mRNA with high codon specificity in the ribosomal A site between positions 2 and 3. The stop codon UAG is cleaved at a fast rate while UAA and UGA are cleaved with intermediate and slow rates. mRNA cleavage can also occur in the ribosomal E site after peptide release from peptidyl-tRNA in the P site as well as on free 30S subunits. Overexpression of RelE results in the inhibition of bacterial growth and a sharp decrease in colony-forming ability which is inhibited by the labile cognate antitoxin RelB. Overexpression also sharply increases persisters (cells that neither grow or die in presence of bactericidal agent and are largely responsible for high levels of biofilm tolerance to antimicrobials). Acts with RelB as a corepressor of relBE transcription.<ref>PMID:9767574</ref> <ref>PMID:11274135</ref> <ref>PMID:11717402</ref> <ref>PMID:12123459</ref> <ref>PMID:12526800</ref> <ref>PMID:19707553</ref> Seems to be a principal mediator of cell death in liquid media.<ref>PMID:9767574</ref> <ref>PMID:11274135</ref> <ref>PMID:11717402</ref> <ref>PMID:12123459</ref> <ref>PMID:12526800</ref> <ref>PMID:19707553</ref>
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[[Category: Sofos, N.]]
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== References ==
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[[Category: B-me on cys50]]
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<references/>
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[[Category: Nuclease]]
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__TOC__
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[[Category: Relb]]
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</StructureSection>
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[[Category: Ribosome]]
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[[Category: Escherichia coli K-12]]
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[[Category: Stress response]]
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[[Category: Large Structures]]
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[[Category: Toxin]]
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[[Category: Boggild A]]
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[[Category: Toxin/antitoxin system]]
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[[Category: Brodersen DE]]
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[[Category: Translational control]]
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[[Category: Sofos N]]

Current revision

Crystal structure of the isolated E. coli RelE toxin, P212121 form

PDB ID 4fxh

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