4gcx
From Proteopedia
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| - | [[Image:4gcx.jpg|left|200px]] | ||
| - | + | ==tRNA-guanine transglycosylase Y106F, C158V, V233G mutant in complex with preQ1== | |
| + | <StructureSection load='4gcx' size='340' side='right'caption='[[4gcx]], [[Resolution|resolution]] 1.42Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4gcx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Zymomonas_mobilis_subsp._mobilis_ZM4_=_ATCC_31821 Zymomonas mobilis subsp. mobilis ZM4 = ATCC 31821]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GCX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GCX FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.42Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PRF:7-DEAZA-7-AMINOMETHYL-GUANINE'>PRF</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gcx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gcx OCA], [https://pdbe.org/4gcx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gcx RCSB], [https://www.ebi.ac.uk/pdbsum/4gcx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gcx ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/TGT_ZYMMO TGT_ZYMMO] Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).[HAMAP-Rule:MF_00168] | ||
| - | == | + | ==See Also== |
| - | + | *[[TRNA-guanine transglycosylase 3D structures|TRNA-guanine transglycosylase 3D structures]] | |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| - | [[ | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Zymomonas mobilis subsp. mobilis ZM4 = ATCC 31821]] |
| - | [[Category: | + | [[Category: Heine A]] |
| - | [[Category: Heine | + | [[Category: Klebe G]] |
| - | [[Category: Klebe | + | [[Category: Reuter K]] |
| - | [[Category: Reuter | + | [[Category: Schmidt I]] |
| - | [[Category: Schmidt | + | [[Category: Tidten-Luksch N]] |
| - | [[Category: Tidten-Luksch | + | |
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Current revision
tRNA-guanine transglycosylase Y106F, C158V, V233G mutant in complex with preQ1
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