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4gld
From Proteopedia
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| - | [[Image:4gld.jpg|left|200px]] | ||
| - | + | ==Crystal Structure of the complex of type II phospholipase A2 with a designed peptide inhibitor Phe - Leu - Ala - Tyr - Lys at 1.69 A resolution== | |
| + | <StructureSection load='4gld' size='340' side='right'caption='[[4gld]], [[Resolution|resolution]] 1.69Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4gld]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Daboia_russelii_pulchella Daboia russelii pulchella]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GLD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GLD FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.69Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gld FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gld OCA], [https://pdbe.org/4gld PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gld RCSB], [https://www.ebi.ac.uk/pdbsum/4gld PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gld ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/PA2B8_DABRR PA2B8_DABRR] Snake venom phospholipase A2 (PLA2) that shows weak neurotoxicity and medium anticoagulant effects by binding to factor Xa (F10) and inhibiting the prothrombinase activity (IC(50) is 130 nM) (PubMed:18062812). It also damages vital organs such as lung, liver and kidney, displays edema-inducing activities when injected into the foot pads of mice and induces necrosis of muscle cells when injected into the thigh muscle. Has a low enzymatic activity. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.<ref>PMID:18062812</ref> <ref>PMID:2115497</ref> <ref>PMID:8835338</ref> | ||
| - | == | + | ==See Also== |
| - | + | *[[Phospholipase A2 3D structures|Phospholipase A2 3D structures]] | |
| - | + | == References == | |
| - | == | + | <references/> |
| - | [[ | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: Dey | + | [[Category: Daboia russelii pulchella]] |
| - | [[Category: Kaur | + | [[Category: Large Structures]] |
| - | [[Category: Sharma | + | [[Category: Dey S]] |
| - | [[Category: Shukla | + | [[Category: Kaur P]] |
| - | [[Category: Singh | + | [[Category: Sharma S]] |
| - | [[Category: Sinha | + | [[Category: Shukla PK]] |
| - | + | [[Category: Singh TP]] | |
| - | + | [[Category: Sinha M]] | |
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Current revision
Crystal Structure of the complex of type II phospholipase A2 with a designed peptide inhibitor Phe - Leu - Ala - Tyr - Lys at 1.69 A resolution
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