4gmd

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[[Image:4gmd.jpg|left|200px]]
 
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{{STRUCTURE_4gmd| PDB=4gmd | SCENE= }}
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==The crystal structure of thymidylate kinase from Pseudomonas aeruginosa PAO1 in complex with AZT Monophosphate==
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<StructureSection load='4gmd' size='340' side='right'caption='[[4gmd]], [[Resolution|resolution]] 1.98&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4gmd]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_PAO1 Pseudomonas aeruginosa PAO1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GMD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GMD FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.98&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATM:3-AZIDO-3-DEOXYTHYMIDINE-5-MONOPHOSPHATE'>ATM</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gmd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gmd OCA], [https://pdbe.org/4gmd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gmd RCSB], [https://www.ebi.ac.uk/pdbsum/4gmd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gmd ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/KTHY_PSEAE KTHY_PSEAE] Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity).
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===The crystal structure of thymidylate kinase from Pseudomonas aeruginosa PAO1 in complex with AZT Monophosphate===
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==See Also==
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*[[Thymidylate kinase 3D structures|Thymidylate kinase 3D structures]]
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__TOC__
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==About this Structure==
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</StructureSection>
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[[4gmd]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GMD OCA].
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[[Category: Large Structures]]
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[[Category: Pseudomonas aeruginosa]]
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[[Category: Pseudomonas aeruginosa PAO1]]
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[[Category: DTMP kinase]]
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[[Category: Jedrzejczak R]]
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[[Category: Jedrzejczak, R.]]
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[[Category: Joachimiak A]]
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[[Category: Joachimiak, A.]]
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[[Category: Joachimiak G]]
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[[Category: Joachimiak, G.]]
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[[Category: Sacchettini J]]
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[[Category: MCSG, Midwest Center for Structural Genomics.]]
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[[Category: Tan K]]
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[[Category: MTBI, Structures of Mtb Proteins Conferring Susceptibility to Known Mtb Inhibitors.]]
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[[Category: Sacchettini, J.]]
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[[Category: Tan, K.]]
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[[Category: Mcsg]]
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[[Category: Midwest center for structural genomic]]
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[[Category: Mtbi]]
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[[Category: Protein structure initiative]]
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[[Category: Psi-biology]]
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[[Category: Structural genomic]]
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[[Category: Structures of mtb proteins conferring susceptibility to known mtb inhibitor]]
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[[Category: Transferase]]
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[[Category: Transferase-inhibitor complex]]
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Current revision

The crystal structure of thymidylate kinase from Pseudomonas aeruginosa PAO1 in complex with AZT Monophosphate

PDB ID 4gmd

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