3uzs

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[[Image:3uzs.png|left|200px]]
 
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{{STRUCTURE_3uzs| PDB=3uzs | SCENE= }}
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==Structure of the C13.28 RNA Aptamer Bound to the G Protein-Coupled Receptor Kinase 2-Heterotrimeric G Protein Beta 1 and Gamma 2 Subunit Complex==
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<StructureSection load='3uzs' size='340' side='right'caption='[[3uzs]], [[Resolution|resolution]] 4.52&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3uzs]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UZS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UZS FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 4.52&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CMT:O-METHYLCYSTEINE'>CMT</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3uzs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uzs OCA], [https://pdbe.org/3uzs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3uzs RCSB], [https://www.ebi.ac.uk/pdbsum/3uzs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3uzs ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ARBK1_BOVIN ARBK1_BOVIN] Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner (By similarity).
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===Structure of the C13.28 RNA Aptamer Bound to the G Protein-Coupled Receptor Kinase 2-Heterotrimeric G Protein Beta 1 and Gamma 2 Subunit Complex===
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==See Also==
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*[[Beta adrenergic receptor kinase 3D structures|Beta adrenergic receptor kinase 3D structures]]
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{{ABSTRACT_PUBMED_22727813}}
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*[[Transducin 3D structures|Transducin 3D structures]]
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__TOC__
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==About this Structure==
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</StructureSection>
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[[3uzs]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UZS OCA].
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==Reference==
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<ref group="xtra">PMID:022727813</ref><references group="xtra"/>
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[[Category: Bos taurus]]
[[Category: Bos taurus]]
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[[Category: Tesmer, J J.G.]]
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[[Category: Large Structures]]
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[[Category: Tesmer, V M.]]
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[[Category: Tesmer JJG]]
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[[Category: Beta propeller]]
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[[Category: Tesmer VM]]
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[[Category: Carboxymethylation]]
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[[Category: G protein-coupled receptor phosphorylation]]
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[[Category: Geranylgeranylation]]
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[[Category: Pleckstrin homology domain]]
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[[Category: Protein kinase fold]]
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[[Category: Protein-rna complex]]
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[[Category: Rgs homology domain]]
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[[Category: Rna aptamer]]
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[[Category: Transferase-rna complex]]
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Current revision

Structure of the C13.28 RNA Aptamer Bound to the G Protein-Coupled Receptor Kinase 2-Heterotrimeric G Protein Beta 1 and Gamma 2 Subunit Complex

PDB ID 3uzs

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