4duc

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[[Image:4duc.png|left|200px]]
 
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{{STRUCTURE_4duc| PDB=4duc | SCENE= }}
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==cytochrome P450 BM3h-2G9 MRI sensor, no ligand==
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<StructureSection load='4duc' size='340' side='right'caption='[[4duc]], [[Resolution|resolution]] 1.92&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4duc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Priestia_megaterium Priestia megaterium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DUC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DUC FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.92&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4duc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4duc OCA], [https://pdbe.org/4duc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4duc RCSB], [https://www.ebi.ac.uk/pdbsum/4duc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4duc ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CPXB_PRIM2 CPXB_PRIM2] Functions as a fatty acid monooxygenase (PubMed:3106359, PubMed:1727637, PubMed:16566047, PubMed:7578081, PubMed:11695892, PubMed:14653735, PubMed:16403573, PubMed:18004886, PubMed:17077084, PubMed:17868686, PubMed:18298086, PubMed:18619466, PubMed:18721129, PubMed:19492389, PubMed:20180779, PubMed:21110374, PubMed:21875028). Catalyzes hydroxylation of fatty acids at omega-1, omega-2 and omega-3 positions (PubMed:1727637, PubMed:21875028). Shows activity toward medium and long-chain fatty acids, with optimum chain lengths of 12, 14 and 16 carbons (lauric, myristic, and palmitic acids). Able to metabolize some of these primary metabolites to secondary and tertiary products (PubMed:1727637). Marginal activity towards short chain lengths of 8-10 carbons (PubMed:1727637, PubMed:18619466). Hydroxylates highly branched fatty acids, which play an essential role in membrane fluidity regulation (PubMed:16566047). Also displays a NADPH-dependent reductase activity in the C-terminal domain, which allows electron transfer from NADPH to the heme iron of the cytochrome P450 N-terminal domain (PubMed:3106359, PubMed:1727637, PubMed:16566047, PubMed:7578081, PubMed:11695892, PubMed:14653735, PubMed:16403573, PubMed:18004886, PubMed:17077084, PubMed:17868686, PubMed:18298086, PubMed:18619466, PubMed:18721129, PubMed:19492389, PubMed:20180779, PubMed:21110374, PubMed:21875028). Involved in inactivation of quorum sensing signals of other competing bacteria by oxidazing efficiently acyl homoserine lactones (AHLs), molecules involved in quorum sensing signaling pathways, and their lactonolysis products acyl homoserines (AHs) (PubMed:18020460).<ref>PMID:11695892</ref> <ref>PMID:14653735</ref> <ref>PMID:16403573</ref> <ref>PMID:16566047</ref> <ref>PMID:17077084</ref> <ref>PMID:1727637</ref> <ref>PMID:17868686</ref> <ref>PMID:18004886</ref> <ref>PMID:18020460</ref> <ref>PMID:18298086</ref> <ref>PMID:18619466</ref> <ref>PMID:18721129</ref> <ref>PMID:19492389</ref> <ref>PMID:20180779</ref> <ref>PMID:21110374</ref> <ref>PMID:21875028</ref> <ref>PMID:3106359</ref> <ref>PMID:7578081</ref>
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===cytochrome P450 BM3h-2G9 MRI sensor, no ligand===
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==See Also==
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*[[Cytochrome P450 3D structures|Cytochrome P450 3D structures]]
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{{ABSTRACT_PUBMED_22659321}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[4duc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_megaterium Bacillus megaterium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DUC OCA].
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</StructureSection>
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[[Category: Large Structures]]
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==Reference==
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[[Category: Priestia megaterium]]
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<ref group="xtra">PMID:022659321</ref><references group="xtra"/>
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[[Category: Arnold FH]]
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[[Category: Bacillus megaterium]]
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[[Category: Brustad EM]]
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[[Category: Unspecific monooxygenase]]
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[[Category: Crook N]]
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[[Category: Arnold, F H.]]
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[[Category: Jasanoff A]]
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[[Category: Brustad, E M.]]
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[[Category: Lelyveld VS]]
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[[Category: Crook, N.]]
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[[Category: Martinez FM]]
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[[Category: Jasanoff, A.]]
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[[Category: Scholl TJ]]
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[[Category: Lelyveld, V S.]]
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[[Category: Snow CD]]
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[[Category: Martinez, F M.]]
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[[Category: Scholl, T J.]]
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[[Category: Snow, C D.]]
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[[Category: Cytochrome p450]]
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[[Category: Directed evolution]]
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[[Category: Mri contrast sensor]]
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[[Category: Oxidoreductase]]
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Current revision

cytochrome P450 BM3h-2G9 MRI sensor, no ligand

PDB ID 4duc

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