4euw

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[[Image:4euw.png|left|200px]]
 
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{{STRUCTURE_4euw| PDB=4euw | SCENE= }}
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==Crystal structure of a HMG domain of transcription factor SOX-9 bound to DNA (SOX-9/DNA) from Homo sapiens at 2.77 A resolution==
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<StructureSection load='4euw' size='340' side='right'caption='[[4euw]], [[Resolution|resolution]] 2.77&Aring;' scene=''>
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===Crystal structure of a HMG domain of transcription factor SOX-9 bound to DNA (SOX-9/DNA) from Homo sapiens at 2.77 A resolution===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4euw]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EUW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EUW FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.77&#8491;</td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4euw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4euw OCA], [https://pdbe.org/4euw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4euw RCSB], [https://www.ebi.ac.uk/pdbsum/4euw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4euw ProSAT]</span></td></tr>
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[[4euw]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EUW OCA].
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/SOX9_HUMAN SOX9_HUMAN] Campomelic dysplasia;46,XX testicular disorder of sex development;46,XX ovotesticular disorder of sex development. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
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== Function ==
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[https://www.uniprot.org/uniprot/SOX9_HUMAN SOX9_HUMAN] Plays an important role in the normal skeletal development. May regulate the expression of other genes involved in chondrogenesis by acting as a transcription factor for these genes.
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: JCSG, Joint Center for Structural Genomics.]]
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[[Category: Large Structures]]
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[[Category: STEMCELL, Partnership for Stem Cell Biology.]]
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[[Category: Activator]]
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[[Category: Dna-binding]]
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[[Category: Hmg domain]]
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[[Category: Jcsg]]
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[[Category: Joint center for structural genomic]]
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[[Category: Nucleus]]
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[[Category: Partnership for stem cell biology]]
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[[Category: Protein structure initiative]]
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[[Category: Protein-dna complex]]
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[[Category: Psi-biology]]
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[[Category: Stemcell]]
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[[Category: Structural genomic]]
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[[Category: Transcription]]
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[[Category: Transcription regulation]]
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[[Category: Transcription-dna complex]]
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Current revision

Crystal structure of a HMG domain of transcription factor SOX-9 bound to DNA (SOX-9/DNA) from Homo sapiens at 2.77 A resolution

PDB ID 4euw

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