4b8l
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 4b8l is ON HOLD until Paper Publication Authors: Sessa, F., Villa, F. Description: Aurora B kinase P353G mutant) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Aurora B kinase P353G mutant== | |
| + | <StructureSection load='4b8l' size='340' side='right'caption='[[4b8l]], [[Resolution|resolution]] 3.00Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4b8l]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B8L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4B8L FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A0P:9-{5-O-[(R)-HYDROXY{[(R)-HYDROXY(PHOSPHONOAMINO)PHOSPHORYL]OXY}PHOSPHORYL]-ALPHA-L-ARABINOFURANOSYL}-9H-PURIN-6-AMINE'>A0P</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4b8l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b8l OCA], [https://pdbe.org/4b8l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4b8l RCSB], [https://www.ebi.ac.uk/pdbsum/4b8l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4b8l ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/INCEA_XENLA INCEA_XENLA] Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Probably acts through association with aurkb or aurkc. Seems to bind directly to microtubules.<ref>PMID:12221116</ref> <ref>PMID:17199039</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Centromere protein 3D structure|Centromere protein 3D structure]] | |
| - | + | *[[Serine/threonine protein kinase 3D structures|Serine/threonine protein kinase 3D structures]] | |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Xenopus laevis]] | ||
| + | [[Category: Sessa F]] | ||
| + | [[Category: Villa F]] | ||
Current revision
Aurora B kinase P353G mutant
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