4gow

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'''Unreleased structure'''
 
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The entry 4gow is ON HOLD
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==Crystal Structure of Ca2+/CaM:Kv7.4 (KCNQ4) B helix complex==
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<StructureSection load='4gow' size='340' side='right'caption='[[4gow]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4gow]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GOW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GOW FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gow FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gow OCA], [https://pdbe.org/4gow PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gow RCSB], [https://www.ebi.ac.uk/pdbsum/4gow PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gow ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/CALM1_HUMAN CALM1_HUMAN] The disease is caused by mutations affecting the gene represented in this entry. Mutations in CALM1 are the cause of CPVT4. The disease is caused by mutations affecting the gene represented in this entry. Mutations in CALM1 are the cause of LQT14.
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== Function ==
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[https://www.uniprot.org/uniprot/CALM1_HUMAN CALM1_HUMAN] Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (PubMed:16760425). Mediates calcium-dependent inactivation of CACNA1C (PubMed:26969752). Positively regulates calcium-activated potassium channel activity of KCNN2 (PubMed:27165696).<ref>PMID:16760425</ref> <ref>PMID:23893133</ref> <ref>PMID:26969752</ref> <ref>PMID:27165696</ref>
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Authors: Xu, Q., Minor Jr., D.L., Chang, A., Tolia, A.
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==See Also==
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*[[Calmodulin 3D structures|Calmodulin 3D structures]]
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Description: Protein complex
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Chang A]]
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[[Category: Minor Jr DL]]
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[[Category: Tolia A]]
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[[Category: Xu Q]]

Current revision

Crystal Structure of Ca2+/CaM:Kv7.4 (KCNQ4) B helix complex

PDB ID 4gow

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