4gr9
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Synthesis of novel MT3 receptor ligands via unusual Knoevenagel condensation== | |
| + | <StructureSection load='4gr9' size='340' side='right'caption='[[4gr9]], [[Resolution|resolution]] 2.29Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4gr9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GR9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GR9 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.291Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=372:N-[(3R)-3-(CYANOMETHYL)-1-METHYL-2-OXO-2,3-DIHYDRO-1H-INDOL-5-YL]ACETAMIDE'>372</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gr9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gr9 OCA], [https://pdbe.org/4gr9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gr9 RCSB], [https://www.ebi.ac.uk/pdbsum/4gr9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gr9 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/NQO2_HUMAN NQO2_HUMAN] The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.<ref>PMID:18254726</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Quinone reductase 3D structures|Quinone reductase 3D structures]] | |
| - | + | == References == | |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Jensen KC]] | ||
| + | [[Category: Lozinskaya NA]] | ||
| + | [[Category: Mesecar AD]] | ||
| + | [[Category: Proskurnina MV]] | ||
| + | [[Category: Sosonyuk SE]] | ||
| + | [[Category: Volkova MS]] | ||
| + | [[Category: Zefirov NS]] | ||
Current revision
Synthesis of novel MT3 receptor ligands via unusual Knoevenagel condensation
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