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4guy
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 4guy is ON HOLD Authors: Calderone, V., Fragai, M., Luchinat, C., Massaro, A., Mordini, A., Mori, M. Description: HUMAN MMP12 CATALYTIC DOMAIN IN C...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Human MMP12 catalytic domain in complex with*N*-Hydroxy-2-(2-(4-methoxyphenyl)ethylsulfonamido)acetamide== | |
| + | <StructureSection load='4guy' size='340' side='right'caption='[[4guy]], [[Resolution|resolution]] 2.00Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4guy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3rtu 3rtu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GUY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GUY FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=KLJ:N-HYDROXY-N~2~-{[2-(4-METHOXYPHENYL)ETHYL]SULFONYL}GLYCINAMIDE'>KLJ</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4guy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4guy OCA], [https://pdbe.org/4guy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4guy RCSB], [https://www.ebi.ac.uk/pdbsum/4guy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4guy ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/MMP12_HUMAN MMP12_HUMAN] May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3. | ||
| - | + | ==See Also== | |
| - | + | *[[Matrix metalloproteinase 3D structures|Matrix metalloproteinase 3D structures]] | |
| - | + | __TOC__ | |
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Calderone V]] | ||
| + | [[Category: Fragai M]] | ||
| + | [[Category: Luchinat C]] | ||
| + | [[Category: Massaro A]] | ||
| + | [[Category: Mordini A]] | ||
| + | [[Category: Mori M]] | ||
Current revision
Human MMP12 catalytic domain in complex with*N*-Hydroxy-2-(2-(4-methoxyphenyl)ethylsulfonamido)acetamide
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Categories: Homo sapiens | Large Structures | Calderone V | Fragai M | Luchinat C | Massaro A | Mordini A | Mori M
