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3ur9

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[[Image:3ur9.jpg|left|200px]]
 
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{{STRUCTURE_3ur9| PDB=3ur9 | SCENE= }}
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==1.65A resolution structure of Norwalk Virus Protease Containing a covalently bound dipeptidyl inhibitor==
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<StructureSection load='3ur9' size='340' side='right'caption='[[3ur9]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3ur9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Norovirus_Hu/1968/US Norovirus Hu/1968/US]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UR9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UR9 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.65&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=K36:(1S,2S)-2-({N-[(BENZYLOXY)CARBONYL]-L-LEUCYL}AMINO)-1-HYDROXY-3-[(3S)-2-OXOPYRROLIDIN-3-YL]PROPANE-1-SULFONIC+ACID'>K36</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ur9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ur9 OCA], [https://pdbe.org/3ur9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ur9 RCSB], [https://www.ebi.ac.uk/pdbsum/3ur9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ur9 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/POLG_NVN68 POLG_NVN68] Protein p48 may play a role in viral replication by interacting with host VAPA, a vesicle-associated membrane protein that plays a role in SNARE-mediated vesicle fusion. This interaction may target replication complex to intracellular membranes.<ref>PMID:569187</ref> <ref>PMID:11160659</ref> NTPase presumably plays a role in replication. Despite having similarities with helicases, does not seem to display any helicase activity.<ref>PMID:569187</ref> <ref>PMID:11160659</ref> Protein P22 may play a role in targeting replication complex to intracellular membranes.<ref>PMID:569187</ref> <ref>PMID:11160659</ref> Viral genome-linked protein is covalently linked to the 5'-end of the positive-strand, negative-strand genomic RNAs and subgenomic RNA. Acts as a genome-linked replication primer. May recruit ribosome to viral RNA thereby promoting viral proteins translation.<ref>PMID:569187</ref> <ref>PMID:11160659</ref> 3C-like protease processes the polyprotein: 3CLpro-RdRp is first released by autocleavage, then all other proteins are cleaved. May cleave host polyadenylate-binding protein thereby inhibiting cellular translation (By similarity).<ref>PMID:569187</ref> <ref>PMID:11160659</ref> RNA-directed RNA polymerase replicates genomic and antigenomic RNA by recognizing replications specific signals. Transcribes also a subgenomic mRNA by initiating RNA synthesis internally on antigenomic RNA. This sgRNA encodes for structural proteins. Catalyzes the covalent attachment VPg with viral RNAs (By similarity).<ref>PMID:569187</ref> <ref>PMID:11160659</ref>
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===1.65A resolution structure of Norwalk Virus Protease Containing a covalently bound dipeptidyl inhibitor===
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==See Also==
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*[[Virus protease 3D structures|Virus protease 3D structures]]
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{{ABSTRACT_PUBMED_22915796}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[3ur9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Norovirus Norovirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UR9 OCA].
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</StructureSection>
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[[Category: Calicivirin]]
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[[Category: Large Structures]]
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[[Category: Norovirus]]
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[[Category: Norovirus Hu/1968/US]]
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[[Category: Alliston, K R.]]
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[[Category: Alliston KR]]
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[[Category: Battaile, K P.]]
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[[Category: Battaile KP]]
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[[Category: Chang, K O.]]
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[[Category: Chang KO]]
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[[Category: Groutas, W C.]]
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[[Category: Groutas WC]]
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[[Category: Kim, Y.]]
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[[Category: Kim Y]]
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[[Category: Lovell, S.]]
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[[Category: Lovell S]]
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[[Category: Mandadapu, S R.]]
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[[Category: Mandadapu SR]]
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[[Category: Tiew, K C.]]
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[[Category: Tiew KC]]
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[[Category: Antiviral inhibitor]]
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[[Category: Dipeptidyl inhibitor]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Norovirus]]
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[[Category: Norwalk virus]]
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[[Category: Protease]]
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Current revision

1.65A resolution structure of Norwalk Virus Protease Containing a covalently bound dipeptidyl inhibitor

PDB ID 3ur9

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