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4fs0

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[[Image:4fs0.png|left|200px]]
 
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{{STRUCTURE_4fs0| PDB=4fs0 | SCENE= }}
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==Crystal structure of mutant F136D of mouse nectin-2 extracellular fragment D1-D2==
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<StructureSection load='4fs0' size='340' side='right'caption='[[4fs0]], [[Resolution|resolution]] 3.25&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4fs0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FS0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FS0 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.25&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fs0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fs0 OCA], [https://pdbe.org/4fs0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fs0 RCSB], [https://www.ebi.ac.uk/pdbsum/4fs0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fs0 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NECT2_MOUSE NECT2_MOUSE] Modulator of T-cell signaling. Can be either a costimulator of T-cell function, or a coinhibitor, depending on the receptor it binds to. Upon binding to CD226, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Upon interaction with PVRIG, inhibits T-cell proliferation. These interactions are competitive. Probable cell adhesion protein.[UniProtKB:Q92692]
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===Crystal structure of mutant F136D of mouse nectin-2 extracellular fragment D1-D2===
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==See Also==
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*[[Poliovirus receptor-related protein|Poliovirus receptor-related protein]]
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{{ABSTRACT_PUBMED_22902367}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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[[4fs0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FS0 OCA].
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[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Brasch, J.]]
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[[Category: Brasch J]]
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[[Category: Harrison, O J.]]
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[[Category: Harrison OJ]]
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[[Category: Shapiro, L.]]
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[[Category: Shapiro L]]
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[[Category: Cell adhesion]]
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[[Category: Ig domain]]
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[[Category: Immunoglobulin-like domain]]
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[[Category: Viral entry receptor]]
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Current revision

Crystal structure of mutant F136D of mouse nectin-2 extracellular fragment D1-D2

PDB ID 4fs0

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