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4fxo
From Proteopedia
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| - | [[Image:4fxo.png|left|200px]] | ||
| - | + | ==Zinc-mediated allosteric inhibiton of caspase-6== | |
| + | <StructureSection load='4fxo' size='340' side='right'caption='[[4fxo]], [[Resolution|resolution]] 2.85Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4fxo]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FXO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FXO FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.85Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fxo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fxo OCA], [https://pdbe.org/4fxo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fxo RCSB], [https://www.ebi.ac.uk/pdbsum/4fxo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fxo ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/CASP6_HUMAN CASP6_HUMAN] Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death. | ||
| - | == | + | ==See Also== |
| - | + | *[[Caspase 3D structures|Caspase 3D structures]] | |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
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| - | [[ | + | |
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Hardy JA]] |
| - | [[Category: | + | [[Category: Velazquez-Delgado EM]] |
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Current revision
Zinc-mediated allosteric inhibiton of caspase-6
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