2lt7
From Proteopedia
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| - | [[Image:2lt7.jpg|left|200px]] | ||
| - | + | ==Solution NMR structure of Kaiso zinc finger DNA binding domain in complex with Kaiso binding site DNA== | |
| - | + | <StructureSection load='2lt7' size='340' side='right'caption='[[2lt7]]' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[2lt7]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LT7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LT7 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |
| - | == | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| - | [[2lt7]] is a 3 chain structure with sequence from [ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lt7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lt7 OCA], [https://pdbe.org/2lt7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lt7 RCSB], [https://www.ebi.ac.uk/pdbsum/2lt7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lt7 ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/KAISO_HUMAN KAISO_HUMAN] Transcriptional regulator with bimodal DNA-binding specificity. Binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' and also binds to the non-methylated consensus sequence 5'-CTGCNA-3'. Recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. May contribute to the repression of target genes of the Wnt signaling pathway. May also activate transcription of a subset of target genes by the recruitment of CTNND2.<ref>PMID:11445535</ref> <ref>PMID:14527417</ref> <ref>PMID:15548582</ref> <ref>PMID:15817151</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Buck-Koehntop | + | [[Category: Large Structures]] |
| - | [[Category: Dyson | + | [[Category: Buck-Koehntop BA]] |
| - | [[Category: Ekiert | + | [[Category: Dyson H]] |
| - | [[Category: Martinez-Yamout | + | [[Category: Ekiert DC]] |
| - | [[Category: Stanfield | + | [[Category: Martinez-Yamout MA]] |
| - | [[Category: Wilson | + | [[Category: Stanfield RL]] |
| - | [[Category: Wright | + | [[Category: Wilson IA]] |
| - | + | [[Category: Wright PE]] | |
| - | + | ||
| - | + | ||
Current revision
Solution NMR structure of Kaiso zinc finger DNA binding domain in complex with Kaiso binding site DNA
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