3t9o

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[[Image:3t9o.jpg|left|200px]]
 
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{{STRUCTURE_3t9o| PDB=3t9o | SCENE= }}
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==Regulatory CZB domain of DgcZ==
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<StructureSection load='3t9o' size='340' side='right'caption='[[3t9o]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3t9o]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T9O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3T9O FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3t9o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3t9o OCA], [https://pdbe.org/3t9o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3t9o RCSB], [https://www.ebi.ac.uk/pdbsum/3t9o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3t9o ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DGCZ_ECOLI DGCZ_ECOLI] Catalyzes the synthesis of cyclic-di-GMP (c-di-GMP) via the condensation of 2 GTP molecules (PubMed:18713317, PubMed:19460094, PubMed:20582742). May act as a zinc sensor that controls, via c-di-GMP, post-translational events (PubMed:23769666). Overexpression leads to a strong repression of swimming; swimming returnes to normal when residues 206-207 are both mutated to Ala. Overexpression also leads to a reduction in flagellar abundance and a 20-fold increase in c-di-GMP levels in vivo. Required for aminoglycoside-mediated induction of biofilm formation, it also plays a lesser role in biofilm production in response to other classes of translation inhibitors. The c-di-GMP produced by this enzyme up-regulates poly-GlcNAc production as well as the biofilm synthesis protein PgaD, although c-di-GMP is probably not the main inducing principle. C-di-GMP is a second messenger which controls cell surface-associated traits in bacteria (PubMed:19460094).<ref>PMID:19460094</ref> <ref>PMID:20582742</ref> <ref>PMID:23769666</ref> <ref>PMID:18713317</ref>
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===Regulatory CZB domain of YdeH===
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==See Also==
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*[[Diguanylate cyclase|Diguanylate cyclase]]
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== References ==
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==About this Structure==
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<references/>
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[[3t9o]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T9O OCA].
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__TOC__
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[[Category: Diguanylate kinase]]
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</StructureSection>
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[[Category: Escherichia coli]]
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[[Category: Escherichia coli K-12]]
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[[Category: Schirmer, T.]]
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[[Category: Large Structures]]
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[[Category: Zaehringer, F.]]
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[[Category: Schirmer T]]
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[[Category: Czb domain]]
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[[Category: Zaehringer F]]
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[[Category: Diguanylate cyclase]]
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[[Category: Metal binding protein]]
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[[Category: Putative zinc sensor]]
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Current revision

Regulatory CZB domain of DgcZ

PDB ID 3t9o

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