1jnp

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[[Image:1jnp.jpg|left|200px]]<br /><applet load="1jnp" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="1jnp, resolution 2.50&Aring;" />
 
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'''Crystal Structure of Murine Tcl1 at 2.5 Resolution'''<br />
 
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==Overview==
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==Crystal Structure of Murine Tcl1 at 2.5 Resolution==
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Tcl1 and Mtcp1, members of the Tcl1 family, are implicated in T-cell prolymphocytic leukemia. The crystal structure of a dimer of murine Tcl1 has been determined at 2.5 A resolution with an R factor of 0.225. Murine Tcl1, human Tcl1 and Mtcp1 share very similar subunit structures, with RMS differences of 0.6 and 1.4 A for C(alpha) atoms, respectively, while the sequences share 50 and 36% identity, respectively. These structures fold into an eight-stranded beta-barrel of unique topology and high internal symmetry of 1.1-1.3 A for the two halves of human and murine Tcl1 and 1.7 A for Mtcp1, despite the low 12-13% sequence identity. The molecular surfaces of all three structures showed a common planar region which is likely to be involved in protein-protein interactions.
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<StructureSection load='1jnp' size='340' side='right'caption='[[1jnp]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[1jnp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JNP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JNP FirstGlance]. <br>
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1JNP is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JNP OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jnp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jnp OCA], [https://pdbe.org/1jnp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jnp RCSB], [https://www.ebi.ac.uk/pdbsum/1jnp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jnp ProSAT]</span></td></tr>
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==Reference==
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</table>
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Structure of murine Tcl1 at 2.5 A resolution and implications for the TCL oncogene family., Petock JM, Torshin IY, Wang YF, Du Bois GC, Croce CM, Harrison RW, Weber IT, Acta Crystallogr D Biol Crystallogr. 2001 Nov;57(Pt 11):1545-51. Epub 2001, Oct 25. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11679718 11679718]
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== Function ==
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[https://www.uniprot.org/uniprot/TCL1A_MOUSE TCL1A_MOUSE] Enhances the phosphorylation and activation of AKT1 and AKT2. Enhances cell proliferation, stabilizes mitochondrial membrane potential and promotes cell survival (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jn/1jnp_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jnp ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Single protein]]
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[[Category: Croce CM]]
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[[Category: Croce, C M.]]
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[[Category: DuBois GC]]
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[[Category: DuBois, G C.]]
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[[Category: Harrison RW]]
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[[Category: Harrison, R W.]]
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[[Category: Petock JM]]
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[[Category: Petock, J M.]]
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[[Category: Torshin IY]]
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[[Category: Torshin, I Y.]]
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[[Category: Wang YF]]
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[[Category: Wang, Y F.]]
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[[Category: Weber IT]]
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[[Category: Weber, I T.]]
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[[Category: beta barrel]]
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[[Category: dimer]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:24:37 2008''
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Current revision

Crystal Structure of Murine Tcl1 at 2.5 Resolution

PDB ID 1jnp

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