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4g5q

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[[Image:4g5q.jpg|left|200px]]
 
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{{STRUCTURE_4g5q| PDB=4g5q | SCENE= }}
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==Structure of LGN GL4/Galphai1 complex==
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<StructureSection load='4g5q' size='340' side='right'caption='[[4g5q]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
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===Structure of LGN GL4/Galphai1 complex===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4g5q]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G5Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4G5Q FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
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==About this Structure==
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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[[4g5q]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G5Q OCA].
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4g5q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g5q OCA], [https://pdbe.org/4g5q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4g5q RCSB], [https://www.ebi.ac.uk/pdbsum/4g5q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4g5q ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/GNAI1_HUMAN GNAI1_HUMAN] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.<ref>PMID:17635935</ref> <ref>PMID:17264214</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Jia, M.]]
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[[Category: Large Structures]]
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[[Category: Li, J.]]
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[[Category: Mus musculus]]
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[[Category: Wang, W.]]
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[[Category: Jia M]]
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[[Category: Wen, W.]]
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[[Category: Li J]]
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[[Category: Zhang, M.]]
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[[Category: Wang W]]
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[[Category: Zhu, J.]]
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[[Category: Wen W]]
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[[Category: Asymmetric cell division]]
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[[Category: Zhang M]]
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[[Category: Cell cycle-signaling protein complex]]
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[[Category: Zhu J]]
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[[Category: Galpha signaling]]
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[[Category: Galphai]]
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[[Category: Goloco]]
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Current revision

Structure of LGN GL4/Galphai1 complex

PDB ID 4g5q

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