4ehu

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[[Image:4ehu.png|left|200px]]
 
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{{STRUCTURE_4ehu| PDB=4ehu | SCENE= }}
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==Activator of the 2-Hydroxyisocaproyl-CoA Dehydratase from Clostridium difficile with bound ADPNP==
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<StructureSection load='4ehu' size='340' side='right'caption='[[4ehu]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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===Activator of the 2-Hydroxyisocaproyl-CoA Dehydratase from Clostridium difficile with bound ADPNP===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4ehu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Clostridioides_difficile Clostridioides difficile]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EHU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EHU FirstGlance]. <br>
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{{ABSTRACT_PUBMED_22827463}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ehu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ehu OCA], [https://pdbe.org/4ehu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ehu RCSB], [https://www.ebi.ac.uk/pdbsum/4ehu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ehu ProSAT]</span></td></tr>
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[[4ehu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Clostridium_difficile Clostridium difficile]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EHU OCA].
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</table>
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== Function ==
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==Reference==
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[https://www.uniprot.org/uniprot/HADI_CLODI HADI_CLODI] Involved in the reductive branch of L-leucine fermentation. Required for the activation of (R)-2-hydroxyisocaproyl-CoA dehydratase. The reduced activator transfers one electron to the dehydratase concomitant with hydrolysis of ATP. This protein is extremely sensitive towards oxygen.<ref>PMID:15654892</ref> <ref>PMID:22827463</ref>
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<ref group="xtra">PMID:022827463</ref><references group="xtra"/>
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== References ==
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[[Category: Clostridium difficile]]
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<references/>
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[[Category: Dobbek, H.]]
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__TOC__
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[[Category: Knauer, S H.]]
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</StructureSection>
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[[Category: 2-hydroxyisocaproyl-coa dehydratase binding]]
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[[Category: Clostridioides difficile]]
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[[Category: Actin fold]]
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[[Category: Large Structures]]
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[[Category: Atp/adp binding]]
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[[Category: Dobbek H]]
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[[Category: Atpase]]
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[[Category: Knauer SH]]
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[[Category: Electron transfer]]
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[[Category: Electron transport]]
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Current revision

Activator of the 2-Hydroxyisocaproyl-CoA Dehydratase from Clostridium difficile with bound ADPNP

PDB ID 4ehu

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