4g31

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[[Image:4g31.png|left|200px]]
 
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{{STRUCTURE_4g31| PDB=4g31 | SCENE= }}
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==Crystal Structure of GSK6414 Bound to PERK (R587-R1092, delete A660-T867) at 2.28 A Resolution==
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<StructureSection load='4g31' size='340' side='right'caption='[[4g31]], [[Resolution|resolution]] 2.28&Aring;' scene=''>
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===Crystal Structure of GSK6414 Bound to PERK (R587-R1092, delete A660-T867) at 2.28 A Resolution===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4g31]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G31 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4G31 FirstGlance]. <br>
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{{ABSTRACT_PUBMED_22827572}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.28&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0WH:1-[5-(4-AMINO-7-METHYL-7H-PYRROLO[2,3-D]PYRIMIDIN-5-YL)-2,3-DIHYDRO-1H-INDOL-1-YL]-2-[3-(TRIFLUOROMETHYL)PHENYL]ETHANONE'>0WH</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4g31 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g31 OCA], [https://pdbe.org/4g31 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4g31 RCSB], [https://www.ebi.ac.uk/pdbsum/4g31 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4g31 ProSAT]</span></td></tr>
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[[4g31]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G31 OCA].
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</table>
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== Disease ==
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==Reference==
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[https://www.uniprot.org/uniprot/E2AK3_HUMAN E2AK3_HUMAN] Wolcott-Rallison syndrome. The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:10932183</ref>
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<ref group="xtra">PMID:022827572</ref><references group="xtra"/>
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== Function ==
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[https://www.uniprot.org/uniprot/E2AK3_HUMAN E2AK3_HUMAN] Phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis. Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin-D1 (CCND1) (By similarity).
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Non-specific serine/threonine protein kinase]]
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[[Category: Large Structures]]
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[[Category: Axten, J M.]]
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[[Category: Axten JM]]
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[[Category: Gampe, R T.]]
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[[Category: Gampe RT]]
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[[Category: Catalytic domain]]
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[[Category: Deletion mutant]]
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[[Category: Synthetic inhibitor]]
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[[Category: Transferase-transferase inhibitor complex]]
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Current revision

Crystal Structure of GSK6414 Bound to PERK (R587-R1092, delete A660-T867) at 2.28 A Resolution

PDB ID 4g31

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