4fzb
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of thymidylate synthase ThyX complexed to a new inhibitor== | |
| - | + | <StructureSection load='4fzb' size='340' side='right'caption='[[4fzb]], [[Resolution|resolution]] 2.59Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4fzb]] is a 16 chain structure with sequence from [https://en.wikipedia.org/wiki/Paramecium_bursaria_Chlorella_virus_1 Paramecium bursaria Chlorella virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FZB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FZB FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.59Å</td></tr> | |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0VJ:2-HYDROXY-3-(4-METHOXYBENZYL)NAPHTHALENE-1,4-DIONE'>0VJ</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fzb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fzb OCA], [https://pdbe.org/4fzb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fzb RCSB], [https://www.ebi.ac.uk/pdbsum/4fzb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fzb ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/THYX_PBCV1 THYX_PBCV1] Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity). | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Paramecium bursaria Chlorella virus 1]] | ||
| + | [[Category: Basta T]] | ||
| + | [[Category: Becker HF]] | ||
| + | [[Category: Boum Y]] | ||
| + | [[Category: Briffotaux J]] | ||
| + | [[Category: Graille M]] | ||
| + | [[Category: Lamarre-Jouenne I]] | ||
| + | [[Category: Lambry JC]] | ||
| + | [[Category: Liebl U]] | ||
| + | [[Category: Myllylkallio H]] | ||
| + | [[Category: Skouloubris S]] | ||
| + | [[Category: Van Tilbeurgh H]] | ||
Current revision
Structure of thymidylate synthase ThyX complexed to a new inhibitor
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