1jux

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[[Image:1jux.gif|left|200px]]<br /><applet load="1jux" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="1jux, resolution 1.6&Aring;" />
 
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'''1.6A Resolution Crystal Structures of the DNA Octamers d(IUATATAC) and d(ITITACAC):Binding of Two Distamycin Drugs Side-by-Side'''<br />
 
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==Overview==
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==1.6A Resolution Crystal Structures of the DNA Octamers d(IUATATAC) and d(ITITACAC):Binding of Two Distamycin Drugs Side-by-Side==
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The crystal structure of the DNA octamer d(ITITACAC)(2) complexed with distamycin has been determined at 1.6 A resolution and refined to a final R(work) and R(free) of 17.0 and 20.7%, respectively. Two molecules of distamycin bind to the DNA duplex in an antiparallel side-by-side fashion. Each drug molecule covers five base pairs of the DNA duplex, with its amide groups hydrogen-bonding to bases in the proximal DNA strand. These two antiparallel drug molecules are stacked together with the pyrrole rings of one molecule stacking against the amide groups of the other. The present structure emphasizes the features of alternating DNA octamers in interaction with distamycin.
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<StructureSection load='1jux' size='340' side='right'caption='[[1jux]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[1jux]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JUX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JUX FirstGlance]. <br>
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1JUX is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ] with <scene name='pdbligand=DMY:'>DMY</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JUX OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMY:DISTAMYCIN+A'>DMY</scene></td></tr>
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==Reference==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jux FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jux OCA], [https://pdbe.org/1jux PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jux RCSB], [https://www.ebi.ac.uk/pdbsum/1jux PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jux ProSAT]</span></td></tr>
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Structure of d(ITITACAC) complexed with distamycin at 1.6 A resolution., Deng J, Pan B, Sundaralingam M, Acta Crystallogr D Biol Crystallogr. 2003 Dec;59(Pt 12):2342-4. Epub 2003, Nov 27. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=14646114 14646114]
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</table>
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[[Category: Protein complex]]
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__TOC__
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[[Category: Deng, J.]]
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</StructureSection>
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[[Category: Pan, B.]]
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[[Category: Large Structures]]
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[[Category: Sundaralingam, M.]]
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[[Category: Deng J]]
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[[Category: DMY]]
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[[Category: Pan B]]
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[[Category: distamycin]]
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[[Category: Sundaralingam M]]
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[[Category: dna]]
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[[Category: octamer]]
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[[Category: side-by-side]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:27:01 2008''
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Current revision

1.6A Resolution Crystal Structures of the DNA Octamers d(IUATATAC) and d(ITITACAC):Binding of Two Distamycin Drugs Side-by-Side

PDB ID 1jux

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