This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1jya

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (07:56, 3 April 2024) (edit) (undo)
 
(13 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1jya.gif|left|200px]]<br /><applet load="1jya" size="350" color="white" frame="true" align="right" spinBox="true"
 
-
caption="1jya, resolution 1.74&Aring;" />
 
-
'''Crystal Structure of SycE'''<br />
 
-
==Overview==
+
==Crystal Structure of SycE==
-
In the type III secretory system of bacterial pathogens, a large number of sequence-divergent but characteristically small (approximately 14-19 kDa), acidic (pI approximately 4-5) chaperone proteins have been identified. We present the 1.74 A resolution crystal structure of the Yersinia pseudotuberculosis chaperone SycE, whose action in promoting translocation of YopE into host macrophages is essential to Yersinia pathogenesis. SycE, a compact, globular dimer with a novel fold, has two large hydrophobic surface patches that may form binding sites for YopE or other type III components. These patches are formed by structurally key residues that are conserved among many chaperones, suggesting shared structural and functional relationships. A negative electrostatic potential covers almost the entire surface of SycE and is likely conserved in character, but not in detail, among chaperones. The structure provides the first structural insights into possible modes of action of SycE and type III chaperones in general.
+
<StructureSection load='1jya' size='340' side='right'caption='[[1jya]], [[Resolution|resolution]] 1.74&Aring;' scene=''>
-
 
+
== Structural highlights ==
-
==About this Structure==
+
<table><tr><td colspan='2'>[[1jya]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Yersinia_pseudotuberculosis Yersinia pseudotuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JYA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JYA FirstGlance]. <br>
-
1JYA is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Yersinia_pseudotuberculosis Yersinia pseudotuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JYA OCA].
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.74&#8491;</td></tr>
-
 
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-
==Reference==
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jya FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jya OCA], [https://pdbe.org/1jya PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jya RCSB], [https://www.ebi.ac.uk/pdbsum/1jya PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jya ProSAT]</span></td></tr>
-
Structure of the Yersinia type III secretory system chaperone SycE., Birtalan S, Ghosh P, Nat Struct Biol. 2001 Nov;8(11):974-8. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11685245 11685245]
+
</table>
-
[[Category: Single protein]]
+
== Function ==
 +
[https://www.uniprot.org/uniprot/Q663P0_YERPS Q663P0_YERPS] Positive regulator of YopE.[PIRNR:PIRNR011271]
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jy/1jya_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jya ConSurf].
 +
<div style="clear:both"></div>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Large Structures]]
[[Category: Yersinia pseudotuberculosis]]
[[Category: Yersinia pseudotuberculosis]]
-
[[Category: Birtalan, S.]]
+
[[Category: Birtalan S]]
-
[[Category: Ghosh, P.]]
+
[[Category: Ghosh P]]
-
[[Category: specific chaperone]]
+
-
[[Category: type iii secretion]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:28:03 2008''
+

Current revision

Crystal Structure of SycE

PDB ID 1jya

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1jya"
Personal tools